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  1. Urothelial carcinoma shows wide plasticity and broad morphologic spectrum. In many instances, the presence of papillary morphology is reassuring of the urothelial histogenesis of a high-grade invasive lesion b...

    Authors: Daniel Abensur Athanazio, Maiara Ferreira de Souza and Maria Estela Pompeu do Amaral

    Citation: Surgical and Experimental Pathology 2020 3:25

    Content type: Case Report

    Published on:

  2. Lupus mastitis (LM) is a rare complication of systemic lupus erythematosus (SLE) or discoid lupus erythematosus (DLE). The clinical presentations of LM may mimic breast malignancy, and biopsy or excision is us...

    Authors: Mingfei Yan, Philip Bomeisl, Hannah Gilmore, Kwadwo Oduro and Aparna Harbhajanka

    Citation: Surgical and Experimental Pathology 2020 3:24

    Content type: Case Report

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  3. Rosai-Dorfman disease (RDD) is a rare but well-defined, histiocytic proliferative disorder with massive lymphadenopathy.

    Authors: Mohammad Hossein Anbardar, Samaneh Hamzehloo, Fatemeh Fazeli, Soheila Zareifar, Mohammad Hadi Imanieh, Mohammadhossein Bahmanzadegan Jahromi and Amir Mohammad Ghorbani

    Citation: Surgical and Experimental Pathology 2020 3:27

    Content type: Case Report

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  4. Cystic neutrophilic granulomatous mastitis (CNGM) is an uncommon and recently described pattern of granulomatous mastitis. To our knowledge, no cases have been described during chemotherapy for invasive breast...

    Authors: Juliana Ribeiro de Freitas, Maiara Ferreira de Souza, Mayana Lopes, Larissa Bitencourt and Daniel Abensur Athanazio

    Citation: Surgical and Experimental Pathology 2020 3:23

    Content type: Case Report

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  5. The term low-grade oncocytic tumour of kidney is an emerging entity describing CD117-negative and cytokeratin 7-positive indolent tumors with overlapping morphological features between oncocytic tumors.

    Authors: Cláudio Galeno Ramalho de Andrade Melo, Marcus Vinicius Nunes Xavier, Isabela Soares Pimenta and Daniel Abensur Athanazio

    Citation: Surgical and Experimental Pathology 2020 3:22

    Content type: Case Report

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  6. Adenoid cystic carcinoma and primary squamous cell carcinoma are both rare breast neoplasms, which possess drastically different morphological and molecular features as well as distinguishing clinical behavior...

    Authors: Mingfei Yan, Phillip Bomeisl, Hannah Gilmore and Aparna Harbhajanka

    Citation: Surgical and Experimental Pathology 2020 3:20

    Content type: Case Report

    Published on:

  7. Recurrent disease following failed chemotherapy for muscle-invasive urothelial carcinoma (UC) has no universally accepted treatment guidelines. Receptors for luteinizing hormone-releasing hormone (LHRHR) have ...

    Authors: Saba Yasir, Gustavo Fernandez-Castro, Numra Aslam Bajwa, Norman Block, Andrew Schally, Richard Cote and Merce Jorda

    Citation: Surgical and Experimental Pathology 2020 3:19

    Content type: Research

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  8. Coronavirus disease 2019 (COVID-19), which started in Wuhan, China, in late December 2019, was declared a pandemic, infecting more than twelve million people worldwide. Few studies have reported the findings o...

    Authors: Elif Usturalı Keskin, Ebru Tastekin, Nuray Can, İnci Usta, Nermin Tuncbilek, Derya Karabulut, Osman Kula and Onur Kırkızlar

    Citation: Surgical and Experimental Pathology 2020 3:21

    Content type: Case Report

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  9. The World Health Organization’s (WHO) update of 2017 defines the cut-off for BCL2 in immunohistochemistry (IHC) in 50% of stained cells in diffuse large B-cell lymphomas (DLBCL). The WHO’s 2017 classification,...

    Authors: Cristiano Claudino Oliveira, Maria Aparecida Custódio Domingues, Isabela Werneck da Cunha and Fernando Augusto Soares

    Citation: Surgical and Experimental Pathology 2020 3:18

    Content type: Research

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  10. The Notch signaling pathway and its modulators are directly related to growth, verticalization and metastasis in melanoma, being a possible therapeutic target for the treatment of this type of cancer. There ar...

    Authors: Lorena Dal Collina Sangiuliano, Renato Santos de Oliveira Filho, Daniel Arcuschin de Oliveira, Heitor Carvalho Gomes and Lydia Masako Ferreira

    Citation: Surgical and Experimental Pathology 2020 3:17

    Content type: Review

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  11. Eccrine porocarcinoma is a rare malignancy accounting for 0.005 to 0.01% of all cutaneous tumors. However, its etiology is not well established. Herein we are reporting the occurrence of metastatic porocarcino...

    Authors: Mitul B. Modi, Ata S. Moshiri, Toru Shoji, Martin C. Mihm Jr, Xiaowei Xu and David E. Elder

    Citation: Surgical and Experimental Pathology 2020 3:16

    Content type: Case Report

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  12. To evaluate the frequency of divergent differentiations / variant morphology in urothelial carcinoma, and their association with muscle-invasive disease at diagnosis.

    Authors: Suelen Cunha Santana, Maiara Ferreira de Souza, Maria Estela Pompeu Amaral and Daniel Abensur Athanazio

    Citation: Surgical and Experimental Pathology 2020 3:14

    Content type: Research

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  13. Morphologic distinction between uterine leiomyosarcoma (ULMS) and endometrial stromal sarcoma (ESS) alone is not straightforward and has been shown to be challenging especially with poor differentiation, so im...

    Authors: Mohamed Ali Alabiad, Ola A. Harb, Mustafa Taha Abdelfattah, Basant Sh. El-Shafaay, Ahmed K. El-Taher and Elsayed I. El-Hendawy

    Citation: Surgical and Experimental Pathology 2020 3:13

    Content type: Research

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  14. Benign melanocytic lesions of the prostate are rare and classified as blue nevus or melanosis. Both lesions have about 30 cases each reported in English literature.

    Authors: Maria Estela Pompeu do Amaral and Daniel Abensur Athanazio

    Citation: Surgical and Experimental Pathology 2020 3:12

    Content type: Case Report

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  15. Meckel Gruber Syndrome (MKS) is a rare autosomal recessive malformation syndrome characterized by multiple congenital anomalies ultimately leading to the death of fetus in utero or shortly after birth. It is c...

    Authors: Marquess Raj, Sujata Dhanuka, Prerna Agarwal, Suresh Lakki Reddy and Sethuramalingam Vivekananthan

    Citation: Surgical and Experimental Pathology 2020 3:11

    Content type: Case Report

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  16. Rhabdomyosarcomas with areas reminiscent of adult type rhabdomyoma are rare and almost exclusive of pretreated tumors. We present a case of 17-year-old patient who sought medical assistance due to a right pain...

    Authors: Suelen Cunha Santana, Filip Messias Santana Prado, Marcos Lima de Oliveira Leal, Paulo Athanazio and Daniel Abensur Athanazio

    Citation: Surgical and Experimental Pathology 2020 3:10

    Content type: Case Report

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  17. Angiogenesis is one of the hallmarks of cancer. This complex mechanism of tumor progression provides tumors cells with essential nutrients. There have been a limited number of investigations of markers of angi...

    Authors: Luiz Victor Maia Loureiro, Luciano Neder, Donato Callegaro-Filho, Ludmila de Oliveira Koch, João Norberto Stavale and Suzana Maria Fleury Malheiros

    Citation: Surgical and Experimental Pathology 2020 3:9

    Content type: Research

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  18. Gene mutations correlated with histological and immunohistochemical phenotypes of hepatocellular adenoma were recently identified. Based on these findings, four adenoma subtypes were distinguished. We classify...

    Authors: Carla Henriques Agostini, Osmar Damasceno Ribeiro, Arlete Fernandes, Adriana Caroli-Bottino and Vera Lucia Pannain

    Citation: Surgical and Experimental Pathology 2020 3:8

    Content type: Research

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  19. Local control for the treatment of primary bone tumors is generally delayed following neoadjuvant chemotherapy. This was born out of the historical need to manufacture custom implants when performing limb-salv...

    Authors: Yoav S. Zvi, Amit Singla, Alexander J. Chou, Janet Tingling, Rui Yang, Bang H. Hoang and David S. Geller

    Citation: Surgical and Experimental Pathology 2020 3:5

    Content type: Case Report

    Published on:

  20. The accurate graduation of a phyllodes tumor (PT) is critical for effective treatment as it allows correct surgical management, and avoids inadequate excision for malignant or borderline PT, or surgical overtr...

    Authors: L. F. Rivero, M. S. Graudenz, P. Aschton-Prolla, A. M. Delgado and L. M. Kliemann

    Citation: Surgical and Experimental Pathology 2020 3:7

    Content type: Research

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  21. Elastic fibers deposition is triggered during liver fibrosis and is related to worse clinical prognosis in chronic hepatitis C patients. This study aimed to verify if a new method for elastic fiber quantificat...

    Authors: Carine Leite, Rodrigo Tzovenos Starosta, Eduardo Neubarth Trindade, Manoel Roberto Maciel Trindade, Mário Reis Álvares-da-Silva and Carlos Thadeu Schmidt Cerski

    Citation: Surgical and Experimental Pathology 2020 3:4

    Content type: Research

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  22. Mucinous cystic neoplasms (MCNs) of pancreas are relatively rare, occur almost exclusively in middle-aged females, and are overwhelmingly located in the body and tail of the pancreas, histologically show an ov...

    Authors: Nasir Ud Din, Maha Zubair, Jamshid Abdul-Ghafar and Zubair Ahmad

    Citation: Surgical and Experimental Pathology 2020 3:6

    Content type: Research

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  23. Penile squamous cell carcinoma (PSSC) has some non-PHV associated precursos and lichen planus is not considered one of them.

    Authors: Marcos Lima de Oliveira Leal, Lucas Rosemberg Pellegrino Jorge Alencar, Suelen Cunha Santana, Bianca Carla Azevedo de Souza and Daniel Abensur Athanazio

    Citation: Surgical and Experimental Pathology 2020 3:1

    Content type: Case Report

    Published on:

  24. The use of a circular stapling device to create an anastomosis following colonic or rectal resection is common practice in the United Kingdom. Histopathological analysis of the anastomotic doughnuts produced t...

    Authors: Steven Dixon, Hannah Barrow and Jane Hughes

    Citation: Surgical and Experimental Pathology 2020 3:2

    Content type: Research

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  25. Despite the immunotherapeutics and target therapy agents, the survival of patients with advanced melanoma is still low. Notch signaling is able to regulate many aspects of melanomagenesis. Comparative analyses...

    Authors: Renato Santos de Oliveira Filho, Alexandre Lavorato Soares, Francisco Macedo Paschoal, Gisele Gargantini Rezze, Ebe Oliveira, Ricardo Macarenco, Antonio Carlos Buzaid and Lydia Masako Ferreira

    Citation: Surgical and Experimental Pathology 2019 2:27

    Content type: Review

    Published on:

  26. Leprosy is a major public health concern in many developing countries. Mycobacterium leprae (M. leprae), the causative agent of leprosy, has the ability to parasitize different types of human cells and tissues. I...

    Authors: Cleverson Soares Teixeira, Patricia Pinheiro Montalvão, Isabella Tostes de Oliveira and Patrick Alexander Wachholz

    Citation: Surgical and Experimental Pathology 2019 2:26

    Content type: Case Report

    Published on:

  27. Gastrointestinal Stromal Tumors (GIST) present different types of mutations that may or may not be sensitive to specific target therapy. The laboratory procedure required to prepare histological sections tradi...

    Authors: Denise Barcelos, Karina Funabashi, Susana Mazloum, Mariana Fernandes and Leonardo Cardili

    Citation: Surgical and Experimental Pathology 2019 2:25

    Content type: Technical Note

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  28. Careful pathological analysis of hepatocellular carcinoma (HCC) specimens is essential for definitive diagnosis and patient prognostication. Tumor size and focality, gross patterns, macro- and microvascular in...

    Authors: Sebastião N. Martins-Filho and Venâncio Avancini Ferreira Alves

    Citation: Surgical and Experimental Pathology 2019 2:23

    Content type: Review

    Published on:

  29. Mature brain heterotopic tissue in sacrococcygeal region is a very rare benign congenital abnormality of newborn. To date, only two cases of mature heterotopic brain tissue in the sacrococcygeal region is repo...

    Authors: Ramin Saadaat, Jamshid Abdul-Ghafar, Ahmed Nasir, Soma Rahmani and Hidayatullah Hamidi

    Citation: Surgical and Experimental Pathology 2019 2:24

    Content type: Case Report

    Published on:

  30. Ubiquitin-specific peptidase 22 (USP22) is described as a stem cell (CSC) marker which is involved in many biological processes, including cancer development, cellular growth and differentiation. Sirtuin 1 (SI...

    Authors: Ola A. Harb, Randa Mohamed Kaf, Heba F. Taha, Safa A. Balata, Rehab Hemeda, Ahmed Mohamed Yehia, Loay M. Gertallah and Ahmed Embaby

    Citation: Surgical and Experimental Pathology 2019 2:22

    Content type: Research

    Published on:

  31. Neuroendocrine tumors (NETs) constitute tumors widely distributed and with heterogeneous biological behavior. For gastrointestinal neuroendocrine tumors (GI-NETs) the following prognostic factors have been ide...

    Authors: Maíra Leite Basile, Fábio Seiji Kuga and Fabíola Del Carlo Bernardi

    Citation: Surgical and Experimental Pathology 2019 2:21

    Content type: Research

    Published on:

  32. This review addresses current issues regarding epidermodysplasia verruciformis (EV), which are relevant in clinical practice and to comprehend the mechanisms by which human papillomavirus (HPV) acts in cutaneo...

    Authors: Lana Luiza da Cruz Silva, Walmar Roncalli Pereira de Oliveira and Mirian Nacagami Sotto

    Citation: Surgical and Experimental Pathology 2019 2:20

    Content type: Review

    Published on:

  33. The kidney is the most common site of metastatic disease to the urinary tract. However, tumor characteristics are commonly deceptive, and the diagnosis of metastatic disease to the kidney may be challenging.

    Authors: Dafne C. Andrade, Sheila F. Faraj, Leopoldo Alves Ribeiro Filho and Romulo L. Mattedi

    Citation: Surgical and Experimental Pathology 2019 2:18

    Content type: Case Report

    Published on:

  34. Since histological analysis is the gold standard for melanoma diagnose, to understand possible findings in nevi is the first step to avoid diagnostic errors. The aim of this paper is to describe several histol...

    Authors: José Cândido Caldeira Xavier-Júnior, Juliana Polizel Ocanha-Xavier, Deolino João Camilo-Júnior, Solange Correa Garcia Pires D’ávilla and Neivio José Mattar

    Citation: Surgical and Experimental Pathology 2019 2:19

    Content type: Review

    Published on:

  35. Ameloblastomas are neoplasms that have inspired great controversy and clinical interest; their incidence, radiographic features, treatment and behavior are still discussed quite often in the literature. In 201...

    Authors: Ana Maria Hoyos Cadavid, Juliane Piragine Araujo, Cláudia Malheiros Coutinho-Camillo, Sheyla Bologna, Celso Augusto Lemos Junior and Silvia Vanessa Lourenço

    Citation: Surgical and Experimental Pathology 2019 2:17

    Content type: Review

    Published on:

  36. We report a rare case of cardiac angiosarcoma in a female adolescent patient that is an unusual case of cardiac angiosarcoma. As the initial symptoms are nonspecific our case demonstrated difficulty to establi...

    Authors: Wlisses Ramon Oliveira, Carla Pérez Machado, Marcelo Mendes Las Casas Moreira, Elisa Carvalho de Siqueira, Fabrício Tinôco Alvim de Souza, Fabiano Franco Monteiro Prado, Maria Carolina Barbosa Álvares, Paulo Ramos Botelho Antunes and Cláudia Souza Freitas Faleiro

    Citation: Surgical and Experimental Pathology 2019 2:16

    Content type: Case Report

    Published on:

  37. PD-L1 is an inhibitory ligand that functions as an essential immune checkpoint. FOXP-1 is a member of the FOXP family. STAT-3 plays a critical role in regulation of cell proliferation and survival. The detailed e...

    Authors: Ola A. Harb, Randa Mohamed Kaf, Heba F. Taha, Rham Z. Ahmed, Doaa Mandour, Ahmed Z. Al Attar, Ayman Fathy, Abdelwahab S. Almoregy, Gamal Osman and Loay M. Gertallah

    Citation: Surgical and Experimental Pathology 2019 2:15

    Content type: Research

    Published on:

  38. Canine visceral leishmaniasis is associated with splenic changes that may interfere with the surveillance of blood borne antigens. Dogs with terminal visceral leishmaniasis present with a variety of skin lesio...

    Authors: Claudia C. Santana, Luiz A. R. de Freitas, Geraldo G. S. Oliveira and Washington L. C. dos-Santos

    Citation: Surgical and Experimental Pathology 2019 2:14

    Content type: Research

    Published on:

  39. Mucocutaneous ulcers associated with the Epstein Barr virus constitute an EBV-induced B-cell lymphoproliferative disorder first described in 2010 by Stefan D. Dojcinov et al. These lesions can occur in associa...

    Authors: Karolinne Correia Wanderlei, Danielle Carvalho Quintella, Tullia Cuzzi, Denize D’Azambuja Ramos, José Carlos Morais, Mário Romañach and Cristiane Bedran Milito

    Citation: Surgical and Experimental Pathology 2019 2:13

    Content type: Review

    Published on:

  40. The current classification of renal cell carcinoma (RCC) was formulated at the meeting of the World Health Organization Renal Tumor Panel in 2015, with the results published in the fourth edition of the World ...

    Authors: Brett Delahunt, John N. Eble, Lars Egevad, John Yaxley, Michelle Thunders and Hemamali Samaratunga

    Citation: Surgical and Experimental Pathology 2019 2:10

    Content type: Review

    Published on:

  41. Sinonasal melanomas (SNM) are aggressive neoplasms, which present distinct clinicopathological and molecular aspects when compared to cutaneous melanomas (CM). B-cell-specific moloney murine leukemia virus int...

    Authors: Harim Tavares dos Santos, Juliana de Souza do Nascimento, Fernanda Meireles, João Figueira Scarini, Erika Said Egal, Victor Angelo Montalli, Felipe Paiva Fonseca, Fernanda Viviane Mariano and Albina Altemani

    Citation: Surgical and Experimental Pathology 2019 2:9

    Content type: Research

    Published on:

  42. Epidermal growth factor receptor (EGFR) is a cellular oncoprotein which is overexpressed in many human cancers including a subset of endometrial cancers. Immunohistochemical (IHC) expression of EGFR has been i...

    Authors: Atif Ali Hashmi, Zubaida Fida Hussain, Muhammad Irfan, Maheen Naeem, Shumaila Kanwal Hashmi, Huda Asif, Samina Baloch and Naveen Faridi

    Citation: Surgical and Experimental Pathology 2019 2:8

    Content type: Research

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  43. As Immune checkpoint inhibitors (ICPIs) are changing the standard-care in lung cancer with good clinical activities and durable responses, its indication must be based on the appropriate patient selection once...

    Authors: Antonio V. Alves da Silva, Francisco Martins Neto, Ana Claudia da Silva M. de Oliveira, Benedito A. Carneiro, Marclesson Alves, Cleto Dantas Nogueira and Fabio Tavora

    Citation: Surgical and Experimental Pathology 2019 2:4

    Content type: Research

    Published on:

  44. p16 is the protein product of most commonly involved gene in bladder carcinogenesis. Therefore, we performed an immunohistochemical study to evaluate association of p16 overexpression with prognostic parameter...

    Authors: Atif Ali Hashmi, Zubaida Fida Hussain, Muhammad Irfan, Shumaila Kanwal Hashmi, Huda Asif and Naveen Faridi

    Citation: Surgical and Experimental Pathology 2019 2:3

    Content type: Research

    Published on:

  45. Triple-negative breast cancers are a poor prognostic group of breast cancers that don’t respond to conventional hormonal and her2neu targeted therapy. A subset of triple-negative breast cancer is known to over...

    Authors: Atif Ali Hashmi, Samreen Naz, Shumaila Kanwal Hashmi, Muhammad Irfan, Zubaida Fida Hussain, Erum Yousuf Khan, Huda Asif and Naveen Faridi

    Citation: Surgical and Experimental Pathology 2019 2:6

    Content type: Research

    Published on:

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