Articles

Cribriform-morular variant of papillary thyroid carcinoma with poorly differentiated features: report of a case and review of the literature

Cribrifrom-morular variant of papillary thyroid carcinoma (CMVPTC) is an uncommon thyroid neoplasm that occurs predominantly in women and is sometime associated with familial adenomatous polyposis (FAP). Some ...

Authors: Kusum L. Sharma, Ravi B. Singh, Nisreen Fidda and Ricardo V. Lloyd

Erosive acute colitis associated with intestinal spirochetosis

Although usually believed to be harmless, intestinal spirochetosis may active erosive colitis associated with intestinal spirochetosis that may mimic idiopathic chronic inflammatory bowel disease. Case present...

Authors: Fabio Dantas de Paula, Glicia Estevam de Abreu, Maiara Ferreira de Souza, Luiz Antonio Rodrigues de Freitas and Daniel Abensur Athanazio

Correction to: A call to action: molecular pathology in Brazil

Authors: Isabela Werneck da Cunha, Renata de Almeida Coudry, Mariana Petaccia de Macedo, Emilio Augusto Campos Pereira de Assis, Stephen Stefani and Fernando Augusto Soares

Bubbles in the belly- a case based approach to cystic peritoneal masses

Primary cystic neoplasms of the peritoneum are rare lesions and not commonly encountered in practice. Many intra-abdominal processes may mimic cystic masses within the peritoneal cavity and pose a diagnostic c...

Authors: Savita S. Patil, Parth B. Shah, Jyoti K. Kudrimoti and Leena A. Nakate

Malignant giant solitary fibrous tumour of the mediastinum; masquerading Triton tumour

Malignant Solitary fibrous tumour (SFT) is an uncommon mesenchymal tumour with aggressive clinical behaviour as compared to its benign counterpart. There are only a handful of reports of extra-pleural malignan...

Authors: Arshi Beg, Jeenal Parikh, Amit Janu and Rajiv Kumar Kaushal

A call to action: molecular pathology in Brazil

Adoption of molecular pathology in Brazil is currently very limited. Of note, there are no programs for training new molecular pathologists in the country; thus, documents compiling nationally applicable infor...

Authors: Isabela Werneck da Cunha, Renata de Almeida Coudry, Mariana Petaccia de Macedo, Emilio Augusto Campos Pereira de Assis, Stephen Stefani and Fernando Augusto Soares

TGFβ1 pathway components in breast cancer tissue from aggressive subtypes correlate with better prognostic parameters in ER-positive and p53-negative cancers

TGFβ signaling exerts context-specific effects in breast cancer (BC) pathogenesis and single nucleotide polymorphisms (SNPs) in TGFβ-signaling components play a role in the genetic control of their expression ...

Authors: Glauco Akelinghton Freire Vitiello, Marla Karine Amarante, Jefferson Crespigio, Bruna Karina Banin Hirata, Nathalia de Sousa Pereira, Karen Brajão de Oliveira, Roberta Losi Guembarovski and Maria Angelica Ehara Watanabe

Recurrent lymphangioleiomyomatosis in a lung allograft with COVID-19: autopsy case report and literature review

Lymphangioleiomyomatosis (LAM) is a rare neoplastic disease of the lung with a characteristic feature of diffuse cystic changes in bilateral lungs. Lung transplantation is considered to be one of the effective...

Authors: Sakda Sathirareuangchai, Jenny L. Weon, Suzanne Tintle, Kiran Batra, Shirley X. Yan and Jose R. Torrealba

Assessing viability of a minimally invasive autopsy technique in ascertaining the probable cause of death in patients who were SARS CoV19 positive at the time of their demise

SARS CoV-19 was declared as a pandemic by the World Health Organization (WHO), raising up challenges on various levels ranging from therapeutics to diagnostics. The conventional autopsy technique may pose a he...

Authors: Ajay H. Bhandarwar, Girish D. Bakhshi, Eham Arora, Nikhil Dhimole, Sanjay R. Bijwe, Shubhangi V. Agale, Megha S. Kinake, Shilpa Domkundwar and Yogesh Thube

Parkin and its molecular associations in gliomas – a systematic review

Parkin, a protein encoded by PRKN, discovered in the context of Parkinson’s disease, controls proteasomal degradation by protein ubiquitination and acts on cell cycle control and mitochondrial homeostasis, among ...

Authors: Eduardo Morais de Castro, Leonardo Vinícius Barbosa, João Vitor Alves Ferreira, Diancarlos Pereira de Andrade, Rosiane Guetter Mello, Luiz Fernando Bleggi Torres, Lucia de Noronha and Cleber Machado-Souza

Applicability of PD-L1 tests to tailor triple-negative breast cancer treatment in Brazil

Triple-negative breast cancer (TNBC) is a heterogeneous disease that represents 10–20% of breast cancer cases. The prognosis for advanced TNBC is usually poor, with a median overall survival of approximately 1...

Authors: Kátia Ramos Moreira Leite, Carlos Henrique Barrios, Antônio Carlos Buzaid, Débora Gagliato, Helenice Gobbi and Fernando Soares

Assessment of lymphovascular invasion in early stage endometrial carcinoma -a retrospective study

Endometrial carcinoma is associated with several known prognostic factors. Recently, lymphovascular invasion (LVI) has gained a prominent position in the risk assessment of early endometrioid endometrial carci...

Authors: Ambreen Moatasim, Zujajah Hameed and Imran Ahmad

Karyomegalic interstitial nephritis: diagnosed only when suspected

Karyomegalic interstitial nephritis (KIN) is an uncommon cause of chronic interstitial nephritis that eventually progresses to end-stage renal disease. Overall less than 50 cases have been reported in the lite...

Authors: Monica Sivakumar, Balan Louis Gaspar and Balakrishnan Narasimhan

Tumor extracellular matrix: lessons from the second-harmonic generation microscopy

Extracellular matrix (ECM) represents more than a mere intercellular cement. It is physiologically active in cell communication, adhesion and proliferation. Collagen is the most abundant protein, making up to ...

Authors: Rodrigo de Andrade Natal, Javier Adur, Carlos Lenz Cesar and José Vassallo

Solitary fibrous tumor of the adrenal gland – its biological behavior and report of a new case

A solitary fibrous tumor (SFT) is an uncommon neoplasm of mesenchymal and probably fibroblastic origin, occurring mainly in the extremities, and pleura. However, a primary involvement of endocrine organs is ra...

Authors: S. E. Huisman, I. Verlinden, P. van Battum and J. W. A. Leijtens

Leiomyoadenomatoid tumor of uterus: two case reports with literature review

Adenomatoid tumors (AT) are benign neoplasms of mesothelial origin that occur more frequently in the genital tracts. In uterus, AT are usually located in the subserosa of the cornual myometrium. Microscopicall...

Authors: Flora Ávila Adorno, Karina Munhoz de Paula Alves Coelho, Giuliano Stefanello Bublitz, Jaqueline Stall and Paulo Henrique Condeixa de França

Classification of renal cell tumors – current concepts and use of ancillary tests: recommendations of the Brazilian Society of Pathology

Classification of renal cell carcinomas has become more challenging. The 2016 WHO classification included 14 different subtypes and 4 emerging/provisional entities, and recent literature indicates new entities...

Authors: Daniel Abensur Athanazio, Luciana Schultz Amorim, Isabela Werneck da Cunha, Katia Ramos Moreira Leite, Alexandre Rolim da Paz, Regina de Paula Xavier Gomes, Fabio Rocha Fernandes Tavora, Sheila Friedrich Faraj, Marcela Santos Cavalcanti and Stephania Martins Bezerra

Muscle biopsy essential diagnostic advice for pathologists

Muscle biopsies are important diagnostic procedures in neuromuscular practice. Recent advances in genetic analysis have profoundly modified Myopathology diagnosis.

Authors: Ana Cotta, Elmano Carvalho, Antonio Lopes da-Cunha-Júnior, Jaquelin Valicek, Monica M. Navarro, Sidney Baptista Junior, Eni Braga da Silveira, Maria Isabel Lima, Bruno Arrivabene Cordeiro, Alexandre Faleiros Cauhi, Miriam Melo Menezes, Simone Vilela Nunes, Antonio Pedro Vargas, Rafael Xavier Neto and Julia Filardi Paim

Lymphadenectomy after a positive sentinel node biopsy in patients with cutaneous melanoma. A systematic review

Complete lymph node dissection (CLND) following a positive sentinel lymph node biopsy (SLNB) has been the standard treatment for years. However, there is increasing evidence that CLND could be omitted. Approxi...

Authors: Maribel L. Da Cunha Cosme, Juan F. Liuzzi Samaterra, Saul A. Siso Cardenas and José I. Chaviano Hernández

Correction to: Occurrence of metastatic eccrine porocarcinoma in an immunosuppressed patient

An amendment to this paper has been published and can be accessed via the original article.

Authors: Mitul B. Modi, Ata S. Moshiri, Toru Shoji, Martin C. Mihm Jr, Xiaowei Xu and David E. Elder

IgG4-related lymphadenopathy – a difficult diagnosis

The IgG4-related disease (IgG4-RD) is a systemic immune-mediated non-neoplastic disease associated with IgG4 positive plasma cells and fibrosis that often presents as a mass lesion. Although the disease could ...

Authors: Balan Louis Gaspar

Fine-Needle Aspiration Cytology (FNAC) is a reliable diagnostic tool for small breast lesions (≤ 1.0 cm): a 20-year retrospective study

Breast cancer is a major public health problem worldwide. It is recommended that small breast lesions or those suspicious for malignancy be evaluated via histopathological examination (“core biopsy” or surgica...

Authors: Jessica Aline Tomelin de Cursi, Mariângela Esther Alencar Marques, Cristina Andrea Campos de Assis Cunha Castro, Fernando Carlos Schmitt and Cleverson Teixeira Soares

Expression of interleukin-6 (IL-6), signal transducer and activator of transcription-3 (STAT-3) and telomerase in choriocarcinomas

Blastocyst implantation and neoplastic invasion have some common properties related to tissue invasion, mediated by various cytokines.

Authors: Luciana Pietro, Fátima Bottcher-Luiz, Lício Augusto Velloso, Joseane Morari, Marcelo Nomura and Liliana A. Lucci De Angelo Andrade

Dealing with prostate cancer? Don’t let histiocytic lesions fool you!

Prostate adenocarcinoma has well known benign mimickers. Histiocytic proliferations usually impose differential diagnosis with high-grade component of acinar adenocarcinoma (Gleason pattern 5).

Authors: Maiara Ferreira de Souza, Diogo Diniz de Moraes, Talita Porto da Costa, Juarez Araújo Andrade, Huarne João José Tenório de Macêdo, Augusto Paraíso and Daniel Abensur Athanazio

Carcinomas in the bladder with papillary and pseudopapillary morphology - not always urothelial

Urothelial carcinoma shows wide plasticity and broad morphologic spectrum. In many instances, the presence of papillary morphology is reassuring of the urothelial histogenesis of a high-grade invasive lesion b...

Authors: Daniel Abensur Athanazio, Maiara Ferreira de Souza and Maria Estela Pompeu do Amaral

Lupus mastitis with predominant kappa-restricted plasma cell infiltration: report of a rare case

Lupus mastitis (LM) is a rare complication of systemic lupus erythematosus (SLE) or discoid lupus erythematosus (DLE). The clinical presentations of LM may mimic breast malignancy, and biopsy or excision is us...

Authors: Mingfei Yan, Philip Bomeisl, Hannah Gilmore, Kwadwo Oduro and Aparna Harbhajanka

Rosai-Dorfman disease: a rare presentation with para-aortic and mesenteric lymphadenopathy, hepatosplenomegaly and ascites

Rosai-Dorfman disease (RDD) is a rare but well-defined, histiocytic proliferative disorder with massive lymphadenopathy.

Authors: Mohammad Hossein Anbardar, Samaneh Hamzehloo, Fatemeh Fazeli, Soheila Zareifar, Mohammad Hadi Imanieh, Mohammadhossein Bahmanzadegan Jahromi and Amir Mohammad Ghorbani

Cystic neutrophilic granulomatous mastitis during chemotherapy treatment for invasive breast carcinoma – a rare lesion that simulates tumor progression

Cystic neutrophilic granulomatous mastitis (CNGM) is an uncommon and recently described pattern of granulomatous mastitis. To our knowledge, no cases have been described during chemotherapy for invasive breast...

Authors: Juliana Ribeiro de Freitas, Maiara Ferreira de Souza, Mayana Lopes, Larissa Bitencourt and Daniel Abensur Athanazio

Low-grade oncocytic tumour of kidney (CD117-negative, cytokeratin 7-positive)

The term low-grade oncocytic tumour of kidney is an emerging entity describing CD117-negative and cytokeratin 7-positive indolent tumors with overlapping morphological features between oncocytic tumors.

Authors: Cláudio Galeno Ramalho de Andrade Melo, Marcus Vinicius Nunes Xavier, Isabela Soares Pimenta and Daniel Abensur Athanazio

Concurrent breast adenoid cystic carcinoma and primary squamous cell carcinoma: report of a rare case with single institutional case reviews

Adenoid cystic carcinoma and primary squamous cell carcinoma are both rare breast neoplasms, which possess drastically different morphological and molecular features as well as distinguishing clinical behavior...

Authors: Mingfei Yan, Phillip Bomeisl, Hannah Gilmore and Aparna Harbhajanka

Immunohistochemical expression of receptors for luteinizing hormone-releasing hormone (LHRHR) in muscle-invasive Urothelial carcinoma of urinary bladder: a potential predictive marker for targeted cytotoxic LHRH hybrid analogs

Recurrent disease following failed chemotherapy for muscle-invasive urothelial carcinoma (UC) has no universally accepted treatment guidelines. Receptors for luteinizing hormone-releasing hormone (LHRHR) have ...

Authors: Saba Yasir, Gustavo Fernandez-Castro, Numra Aslam Bajwa, Norman Block, Andrew Schally, Richard Cote and Merce Jorda

Granulomatous inflammation in pulmonary pathology of 2019 novel coronavirus pneumonia: case report with a literature review

Coronavirus disease 2019 (COVID-19), which started in Wuhan, China, in late December 2019, was declared a pandemic, infecting more than twelve million people worldwide. Few studies have reported the findings o...

Authors: Elif Usturalı Keskin, Ebru Tastekin, Nuray Can, İnci Usta, Nermin Tuncbilek, Derya Karabulut, Osman Kula and Onur Kırkızlar

50% versus 70%: is there a difference between these BCL2 cut-offs in immunohistochemistry for diffuse large B-cell lymphomas (DLBCL)?

The World Health Organization’s (WHO) update of 2017 defines the cut-off for BCL2 in immunohistochemistry (IHC) in 50% of stained cells in diffuse large B-cell lymphomas (DLBCL). The WHO’s 2017 classification,...

Authors: Cristiano Claudino Oliveira, Maria Aparecida Custódio Domingues, Isabela Werneck da Cunha and Fernando Augusto Soares

Identification and quantification of notch receptors in human cutaneous melanoma using molecular biology techniques: literature review

The Notch signaling pathway and its modulators are directly related to growth, verticalization and metastasis in melanoma, being a possible therapeutic target for the treatment of this type of cancer. There ar...

Authors: Lorena Dal Collina Sangiuliano, Renato Santos de Oliveira Filho, Daniel Arcuschin de Oliveira, Heitor Carvalho Gomes and Lydia Masako Ferreira

Occurrence of metastatic eccrine porocarcinoma in an immunosuppressed patient

Eccrine porocarcinoma is a rare malignancy accounting for 0.005 to 0.01% of all cutaneous tumors. However, its etiology is not well established. Herein we are reporting the occurrence of metastatic porocarcino...

Authors: Mitul B. Modi, Ata S. Moshiri, Toru Shoji, Martin C. Mihm Jr, Xiaowei Xu and David E. Elder

Fibrosing pneumonia – how to diagnose, and how to recognize the etiology?

Fibrosing pneumonias are a group of interstitial lung diseases with a different etiologic background and divergent prognosis. They are differentiated into usual interstitial pneumonia (UIP), non-specific inter...

Authors: Helmut H.- Popper

Divergent differentiation and variant morphology in invasive urothelial carcinomas – association with muscle-invasive disease

To evaluate the frequency of divergent differentiations / variant morphology in urothelial carcinoma, and their association with muscle-invasive disease at diagnosis.

Authors: Suelen Cunha Santana, Maiara Ferreira de Souza, Maria Estela Pompeu Amaral and Daniel Abensur Athanazio

The values of Transgelin, Stathmin, BCOR and Cyclin-D1 expression in differentiation between Uterine Leiomyosarcoma (ULMS) and Endometrial Stromal Sarcoma (ESS); diagnostic and prognostic implications

Morphologic distinction between uterine leiomyosarcoma (ULMS) and endometrial stromal sarcoma (ESS) alone is not straightforward and has been shown to be challenging especially with poor differentiation, so im...

Authors: Mohamed Ali Alabiad, Ola A. Harb, Mustafa Taha Abdelfattah, Basant Sh. El-Shafaay, Ahmed K. El-Taher and Elsayed I. El-Hendawy

Melanocytic lesions of the prostate

Benign melanocytic lesions of the prostate are rare and classified as blue nevus or melanosis. Both lesions have about 30 cases each reported in English literature.

Authors: Maria Estela Pompeu do Amaral and Daniel Abensur Athanazio

Meckel Gruber syndrome – a case report

Meckel Gruber Syndrome (MKS) is a rare autosomal recessive malformation syndrome characterized by multiple congenital anomalies ultimately leading to the death of fetus in utero or shortly after birth. It is c...

Authors: Marquess Raj, Sujata Dhanuka, Prerna Agarwal, Suresh Lakki Reddy and Sethuramalingam Vivekananthan

Rhabdomyosarcoma with an intratumoral adult type rhabdomyoma nodule with focal neuronal differentiation - diagnosis, prognosis and treatment of a rare disease

Rhabdomyosarcomas with areas reminiscent of adult type rhabdomyoma are rare and almost exclusive of pretreated tumors. We present a case of 17-year-old patient who sought medical assistance due to a right pain...

Authors: Suelen Cunha Santana, Filip Messias Santana Prado, Marcos Lima de Oliveira Leal, Paulo Athanazio and Daniel Abensur Athanazio

The immunohistochemical landscape of the VEGF family and its receptors in glioblastomas

Angiogenesis is one of the hallmarks of cancer. This complex mechanism of tumor progression provides tumors cells with essential nutrients. There have been a limited number of investigations of markers of angi...

Authors: Luiz Victor Maia Loureiro, Luciano Neder, Donato Callegaro-Filho, Ludmila de Oliveira Koch, João Norberto Stavale and Suzana Maria Fleury Malheiros

Relevance of morphological features for hepatocellular adenoma classification in pathology practice

Gene mutations correlated with histological and immunohistochemical phenotypes of hepatocellular adenoma were recently identified. Based on these findings, four adenoma subtypes were distinguished. We classify...

Authors: Carla Henriques Agostini, Osmar Damasceno Ribeiro, Arlete Fernandes, Adriana Caroli-Bottino and Vera Lucia Pannain

Upfront surgical resection for primary bone tumors: rationale and potential benefits

Local control for the treatment of primary bone tumors is generally delayed following neoadjuvant chemotherapy. This was born out of the historical need to manufacture custom implants when performing limb-salv...

Authors: Yoav S. Zvi, Amit Singla, Alexander J. Chou, Janet Tingling, Rui Yang, Bang H. Hoang and David S. Geller

Accuracy of p53 and ki-67 in the graduation of phyllodes tumor, a model for practical application

The accurate graduation of a phyllodes tumor (PT) is critical for effective treatment as it allows correct surgical management, and avoids inadequate excision for malignant or borderline PT, or surgical overtr...

Authors: L. F. Rivero, M. S. Graudenz, P. Aschton-Prolla, A. M. Delgado and L. M. Kliemann

Corrected integrated density: a novel method for liver elastic fibers quantification in chronic hepatitis C

Elastic fibers deposition is triggered during liver fibrosis and is related to worse clinical prognosis in chronic hepatitis C patients. This study aimed to verify if a new method for elastic fiber quantificat...

Authors: Carine Leite, Rodrigo Tzovenos Starosta, Eduardo Neubarth Trindade, Manoel Roberto Maciel Trindade, Mário Reis Álvares-da-Silva and Carlos Thadeu Schmidt Cerski

Pancreatic mucinous cystic neoplasms: a clinicopathological study of 11 cases and detailed review of literature

Mucinous cystic neoplasms (MCNs) of pancreas are relatively rare, occur almost exclusively in middle-aged females, and are overwhelmingly located in the body and tail of the pancreas, histologically show an ov...

Authors: Nasir Ud Din, Maha Zubair, Jamshid Abdul-Ghafar and Zubair Ahmad

Plasmocytoid urothelial carcinoma - clinical, histological, immunohistochemical and molecular aspects

Plasmacytoid (PUC) variant is a rare and aggressive form of urothelial cancer representing 1 to 3% of the bladder cancer. The main differential diagnosis is the bladder involvement by lymphoma-plasmocytoma or ...

Authors: Katia Ramos Moreira Leite

Penile squamous cell carcinoma and lichen planus

Penile squamous cell carcinoma (PSSC) has some non-PHV associated precursos and lichen planus is not considered one of them.

Authors: Marcos Lima de Oliveira Leal, Lucas Rosemberg Pellegrino Jorge Alencar, Suelen Cunha Santana, Bianca Carla Azevedo de Souza and Daniel Abensur Athanazio

Doughnut bother! Histopathological examination of anastomotic doughnuts following colorectal anastomosis does not change patient management

The use of a circular stapling device to create an anastomosis following colonic or rectal resection is common practice in the United Kingdom. Histopathological analysis of the anastomotic doughnuts produced t...

Authors: Steven Dixon, Hannah Barrow and Jane Hughes