Articles

The frequency of high PD-L1 expression is low in lung adenocarcinoma patients from Northeast Brazil

As Immune checkpoint inhibitors (ICPIs) are changing the standard-care in lung cancer with good clinical activities and durable responses, its indication must be based on the appropriate patient selection once...

Authors: Antonio V. Alves da Silva, Francisco Martins Neto, Ana Claudia da Silva M. de Oliveira, Benedito A. Carneiro, Marclesson Alves, Cleto Dantas Nogueira and Fabio Tavora

Prognostic significance of p16 immunohistochemical expression in urothelial carcinoma

p16 is the protein product of most commonly involved gene in bladder carcinogenesis. Therefore, we performed an immunohistochemical study to evaluate association of p16 overexpression with prognostic parameter...

Authors: Atif Ali Hashmi, Zubaida Fida Hussain, Muhammad Irfan, Shumaila Kanwal Hashmi, Huda Asif and Naveen Faridi

Epidermal growth factor receptor (EGFR) overexpression in triple-negative breast cancer: association with clinicopathologic features and prognostic parameters

Triple-negative breast cancers are a poor prognostic group of breast cancers that don’t respond to conventional hormonal and her2neu targeted therapy. A subset of triple-negative breast cancer is known to over...

Authors: Atif Ali Hashmi, Samreen Naz, Shumaila Kanwal Hashmi, Muhammad Irfan, Zubaida Fida Hussain, Erum Yousuf Khan, Huda Asif and Naveen Faridi

miRNAs 144-3p, 34a-5p, and 206 are a useful signature for distinguishing uterine leiomyosarcoma from other smooth muscle tumors

Leiomyosarcoma (LMS) is a rare uterine neoplasm that has a high mortality rate and no specific treatment. The origin of LMS remains unknown; although, it is hypothesized that LMS arises from the malignant tran...

Authors: Beatriz Nunes Schiavon, Katia Candido Carvalho, Cláudia Malheiros Coutinho-Camillo, Glauco Baiocchi, Renan Valieris, Rodrigo Drummond, Israel Tojal da Silva, Louise De Brot, Fernando Augusto Soares and Isabela Werneck da Cunha

Columnar cell lesions of the breast: a practical review for the pathologist

Columnar cell lesions (CCLs) of the breast are characterized by the substitution of regular layer of cuboid epithelial by columnar cells covering the terminal duct lobular units (TDLUs). It also comprises a sp...

Authors: Angela Flavia Logullo and Cristiane Nimir

Mucosal Schwann cell hamartomas do occur the gastric mucosa – report of two cases mimicking fundic gland polyps

Mucosal Schwann cell hamartomas (MSCHs) are recently characterized benign spindle cell lesions of the colon and rectum. There is only one report of MSCHs in the stomach (antrum). Herein, we present the first r...

Authors: Márcia Helena Oliveira Castro, Rodrigo Jose Felipe, Amanda Fernandes Cardoso, Carlos Leonardo Martins Guimarães, Paulo Roberto Fontes Athanazio and Daniel Abensur Athanazio

Identification and immunophenotype of abnormal cells present in focal cortical dysplasia type IIb

Focal cortical dysplasias (FCDs) are malformations of cortical development that present cortical dyslamination and abnormal cell morphology and are frequently associated with refractory epilepsy. FCD type IIb ...

Authors: Gleice K. Sousa, Caroline S. Capitelli, Thaís C. D. Dombroski, César A. B. Zanella, Vera C. Terra, Tonicarlo R. Velasco, Hélio R. Machado, João A. Assirati, Carlos G. Carlotti, Vani M. Alves, Jaderson Costa DaCosta, André L. Palmini, Eliseu Paglioli, Americo C. Sakamoto, Roberto Spreafico, Rita Garbelli…

The papilla as a biomarker in the molecular era of bladder oncology

Conventional optical microscopy has been fundamental in the diagnosis of cancer for over a century. Tumor morphology has prognostic value and impact on treatment choice, but integration with molecular knowledg...

Authors: Luciana Schultz

Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy

Chronic Chagas cardiomyopathy (CCC) is characterized by the presence of a multifocal inflammatory response and myocardial damage, leading to fibrosis, arrhythmias and ventricular dysfunction. The expression of...

Authors: Ticiana Ferreira Larocca, Bruno Solano de Freitas Souza, Carolina Thé Macêdo, Carine Machado Azevedo, Juliana Fraga Vasconcelos, Daniela Nascimento Silva, Diogo Crispim Nascimento Portella, Washington Luis Conrado dos Santos, Fabio Rocha Fernandes Tavora, João David de Souza Neto, Ricardo Ribeiro dos Santos and Milena Botelho Pereira Soares

KIT exon 11 and PDGFRA exon 18 gene mutations in gastric GIST: proposal of a short panel for predicting therapeutic response

GIST is the most common mesenchymal tumor of gastrointestinal tract and is more frequent in stomach. Its main mutations affect KIT and PDGFRA genes. Full genetic analysis panels are currently used to study mutati...

Authors: Denise Barcelos, Ricardo Artigiani Neto, Leonardo Cardili, Mariana Fernandes, Fernando Cintra Lopes Carapeto, Andréia Neves Comodo, Karina Funabashi and Edna Sadayo Miazato Iwamura

Evaluation of aortic changes in elderly people autopsied with acquired immunodeficiency syndrome

To verify the distribution of the degree of fat deposits and percentage of collagen and elastic fibers in the intimal and medial layers of the aorta of elderly patients autopsied, with and without Acquired Imm...

Authors: Mariana Silva Oliveira, Bianca Gonçalves Silva Torquato, Luciano Alves Matias da Silveira, Gabriela Ribeiro Juliano, Laura Sanches Aguiar, Guilherme Ribeiro Juliano, Lívia Ferreira Oliveira, Ana Paula Espindula, Luciana Santos Ramalho, Camila Lourencini Cavellani, Aline Cristina Souza da Silva, Grace Kelly Naves de Aquino Favarato, Vicente de Paula Antunes Teixeira and Mara Lúcia da Fonseca Ferraz

Ileal Dieulafoy Lesion: a rare case report

Dieulafoy lesion, also known as calibre persistent artery is a rare cause of massive GI bleeding. It’s an abnormal sub-mucosal artery protruding from a minute mucosal defect (≤3 mm). Commonest location is in p...

Authors: Aleena Jain, Manjusha Karegar, Amita Joshi and Amey Rojekar

Introducing Surgical and Experimental Pathology

Authors: Fernando Soares

Pulmonary mucinous adenocarcinomas: a clinicopathologic series with emphasis on the prognostic significance of spread through alveolar spaces, and presence of solid growth component

Mucinous adenocarcinoma is often considered a relatively poor prognostic group among adenocarcinomas of the lung and has a high rate of pulmonary recurrence. Pathologic parameters predicting poor outcome have ...

Authors: Adina Paulk, Fabio Tavora and Allen Burke

Current topics on prostate and bladder pathology

This review addresses current issues from the daily practice of prostate and bladder diagnostic pathology.

Authors: Daniel Abensur Athanazio and Vinicius Carrera Souza

Usefulness of IMP3 and FOXP3 to predict metastasis of cutaneous melanomas

Melanoma still has considerable mortality in spite of improvements in diagnosis and treatment. Unfortunately, current diagnostic procedures cannot predict precisely its biological behavior, what urges speciali...

Authors: Juliana Polizel Ocanha-Xavier, José Cândido C. Xavier-Junior and Mariângela Esther Alencar Marques