Articles

Literature review of Notch melanoma receptors

Despite the immunotherapeutics and target therapy agents, the survival of patients with advanced melanoma is still low. Notch signaling is able to regulate many aspects of melanomagenesis. Comparative analyses...

Authors: Renato Santos de Oliveira Filho, Alexandre Lavorato Soares, Francisco Macedo Paschoal, Gisele Gargantini Rezze, Ebe Oliveira, Ricardo Macarenco, Antonio Carlos Buzaid and Lydia Masako Ferreira

Neoplastic cells parasitized by Mycobacterium leprae: report of two cases of melanocytic nevus and one of basal cell carcinoma

Leprosy is a major public health concern in many developing countries. Mycobacterium leprae (M. leprae), the causative agent of leprosy, has the ability to parasitize different types of human cells and tissues. I...

Authors: Cleverson Soares Teixeira, Patricia Pinheiro Montalvão, Isabella Tostes de Oliveira and Patrick Alexander Wachholz

STR technique for the detection of contamination by exogenous DNA in paraffin blocks and histological slides

Gastrointestinal Stromal Tumors (GIST) present different types of mutations that may or may not be sensitive to specific target therapy. The laboratory procedure required to prepare histological sections tradi...

Authors: Denise Barcelos, Karina Funabashi, Susana Mazloum, Mariana Fernandes and Leonardo Cardili

The strengths and weaknesses of gross and histopathological evaluation in hepatocellular carcinoma: a brief review

Careful pathological analysis of hepatocellular carcinoma (HCC) specimens is essential for definitive diagnosis and patient prognostication. Tumor size and focality, gross patterns, macro- and microvascular in...

Authors: Sebastião N. Martins-Filho and Venâncio Avancini Ferreira Alves

Brain ectopic tissue in sacrococcygeal region of a child, clinically mimicking sacrococcygeal teratoma: a case report

Mature brain heterotopic tissue in sacrococcygeal region is a very rare benign congenital abnormality of newborn. To date, only two cases of mature heterotopic brain tissue in the sacrococcygeal region is repo...

Authors: Ramin Saadaat, Jamshid Abdul-Ghafar, Ahmed Nasir, Soma Rahmani and Hidayatullah Hamidi

Clinical, pathological and prognostic implications of USP22, SIRT1 and E-cadherin expression in papillary thyroid cancer (PTC) and adjacent non-neoplastic tissue

Ubiquitin-specific peptidase 22 (USP22) is described as a stem cell (CSC) marker which is involved in many biological processes, including cancer development, cellular growth and differentiation. Sirtuin 1 (SI...

Authors: Ola A. Harb, Randa Mohamed Kaf, Heba F. Taha, Safa A. Balata, Rehab Hemeda, Ahmed Mohamed Yehia, Loay M. Gertallah and Ahmed Embaby

Comparation of the quantification of the proliferative index KI67 between eyeball and semi-automated digital analysis in gastro-intestinal neuroendrocrine tumors

Neuroendocrine tumors (NETs) constitute tumors widely distributed and with heterogeneous biological behavior. For gastrointestinal neuroendocrine tumors (GI-NETs) the following prognostic factors have been ide...

Authors: Maíra Leite Basile, Fábio Seiji Kuga and Fabíola Del Carlo Bernardi

Epidermodysplasia verruciformis: revision of a model of carcinogenic disease

This review addresses current issues regarding epidermodysplasia verruciformis (EV), which are relevant in clinical practice and to comprehend the mechanisms by which human papillomavirus (HPV) acts in cutaneo...

Authors: Lana Luiza da Cruz Silva, Walmar Roncalli Pereira de Oliveira and Mirian Nacagami Sotto

Metastatic colorectal adenocarcinoma in a 76-year old male: a pitfall in the diagnosis for unclassified renal cell carcinoma

The kidney is the most common site of metastatic disease to the urinary tract. However, tumor characteristics are commonly deceptive, and the diagnosis of metastatic disease to the kidney may be challenging.

Authors: Dafne C. Andrade, Sheila F. Faraj, Leopoldo Alves Ribeiro Filho and Romulo L. Mattedi

Interesting overlooked findings in melanocytic nevi

Since histological analysis is the gold standard for melanoma diagnose, to understand possible findings in nevi is the first step to avoid diagnostic errors. The aim of this paper is to describe several histol...

Authors: José Cândido Caldeira Xavier-Júnior, Juliana Polizel Ocanha-Xavier, Deolino João Camilo-Júnior, Solange Correa Garcia Pires D’ávilla and Neivio José Mattar

Ameloblastomas: current aspects of the new WHO classification in an analysis of 136 cases

Ameloblastomas are neoplasms that have inspired great controversy and clinical interest; their incidence, radiographic features, treatment and behavior are still discussed quite often in the literature. In 201...

Authors: Ana Maria Hoyos Cadavid, Juliane Piragine Araujo, Cláudia Malheiros Coutinho-Camillo, Sheyla Bologna, Celso Augusto Lemos Junior and Silvia Vanessa Lourenço

Cardiac angiosarcoma in a female adolescent: a case report

We report a rare case of cardiac angiosarcoma in a female adolescent patient that is an unusual case of cardiac angiosarcoma. As the initial symptoms are nonspecific our case demonstrated difficulty to establi...

Authors: Wlisses Ramon Oliveira, Carla Pérez Machado, Marcelo Mendes Las Casas Moreira, Elisa Carvalho de Siqueira, Fabrício Tinôco Alvim de Souza, Fabiano Franco Monteiro Prado, Maria Carolina Barbosa Álvares, Paulo Ramos Botelho Antunes and Cláudia Souza Freitas Faleiro

Prognostic values and clinical implications of programmed cell death-ligand 1 (PD-L1), fork head transcription factor P-1 (FOXP-1) and signal transducer and activator of transcription-3 (STAT-3) expression in diffuse large B-cell lymphoma (DLBCL); an immunohistochemical study

PD-L1 is an inhibitory ligand that functions as an essential immune checkpoint. FOXP-1 is a member of the FOXP family. STAT-3 plays a critical role in regulation of cell proliferation and survival. The detailed e...

Authors: Ola A. Harb, Randa Mohamed Kaf, Heba F. Taha, Rham Z. Ahmed, Doaa Mandour, Ahmed Z. Al Attar, Ayman Fathy, Abdelwahab S. Almoregy, Gamal Osman and Loay M. Gertallah

Disorganization of spleen compartments and dermatitis in canine visceral leishmaniasis

Canine visceral leishmaniasis is associated with splenic changes that may interfere with the surveillance of blood borne antigens. Dogs with terminal visceral leishmaniasis present with a variety of skin lesio...

Authors: Claudia C. Santana, Luiz A. R. de Freitas, Geraldo G. S. Oliveira and Washington L. C. dos-Santos

EBV-positive mucocutaneous ulcers: a presentation of two cases and a brief literature review

Mucocutaneous ulcers associated with the Epstein Barr virus constitute an EBV-induced B-cell lymphoproliferative disorder first described in 2010 by Stefan D. Dojcinov et al. These lesions can occur in associa...

Authors: Karolinne Correia Wanderlei, Danielle Carvalho Quintella, Tullia Cuzzi, Denize D’Azambuja Ramos, José Carlos Morais, Mário Romañach and Cristiane Bedran Milito

A case series of dermatofibromas originating in leprosy lesions: a potentially misdiagnosed condition

Authors: C. T. Soares, P. Y. Masuda, D. C. Junior, W. A. Belachew and P. A. Wachholz

Apc-related models of intestinal neoplasia: a brief review for pathologists

Rodent models of intestinal cancer are widely used as preclinical models for human colorectal carcinoma and have proven useful in many experimental contexts, including elucidation of basic pathways of carcinog...

Authors: Kay Washington and Annie Elizabeth Dietz Zemper

Emerging entities of renal cell neoplasia

The current classification of renal cell carcinoma (RCC) was formulated at the meeting of the World Health Organization Renal Tumor Panel in 2015, with the results published in the fourth edition of the World ...

Authors: Brett Delahunt, John N. Eble, Lars Egevad, John Yaxley, Michelle Thunders and Hemamali Samaratunga

Evaluation of the expression of Bmi-1 stem cell marker in sinonasal melanomas and its correlation with the expression of cell cycle proteins

Sinonasal melanomas (SNM) are aggressive neoplasms, which present distinct clinicopathological and molecular aspects when compared to cutaneous melanomas (CM). B-cell-specific moloney murine leukemia virus int...

Authors: Harim Tavares dos Santos, Juliana de Souza do Nascimento, Fernanda Meireles, João Figueira Scarini, Erika Said Egal, Victor Angelo Montalli, Felipe Paiva Fonseca, Fernanda Viviane Mariano and Albina Altemani

Epidermal growth factor receptor (EGFR) overexpression in endometrial carcinoma: association with histopathologic parameters

Epidermal growth factor receptor (EGFR) is a cellular oncoprotein which is overexpressed in many human cancers including a subset of endometrial cancers. Immunohistochemical (IHC) expression of EGFR has been i...

Authors: Atif Ali Hashmi, Zubaida Fida Hussain, Muhammad Irfan, Maheen Naeem, Shumaila Kanwal Hashmi, Huda Asif, Samina Baloch and Naveen Faridi

Expression of PD-L1 in primary breast carcinoma and lymph node metastases

Programmed cell death ligand 1 (PD-L1) is a predictive biomarker of the response of immunotherapy in some types of cancer. In the last years it was described its expression in breast cancer, namely in triple-n...

Authors: Alice M. Alves, Joana Paredes and Fernando Schmitt

The frequency of high PD-L1 expression is low in lung adenocarcinoma patients from Northeast Brazil

As Immune checkpoint inhibitors (ICPIs) are changing the standard-care in lung cancer with good clinical activities and durable responses, its indication must be based on the appropriate patient selection once...

Authors: Antonio V. Alves da Silva, Francisco Martins Neto, Ana Claudia da Silva M. de Oliveira, Benedito A. Carneiro, Marclesson Alves, Cleto Dantas Nogueira and Fabio Tavora

Prognostic significance of p16 immunohistochemical expression in urothelial carcinoma

p16 is the protein product of most commonly involved gene in bladder carcinogenesis. Therefore, we performed an immunohistochemical study to evaluate association of p16 overexpression with prognostic parameter...

Authors: Atif Ali Hashmi, Zubaida Fida Hussain, Muhammad Irfan, Shumaila Kanwal Hashmi, Huda Asif and Naveen Faridi

Epidermal growth factor receptor (EGFR) overexpression in triple-negative breast cancer: association with clinicopathologic features and prognostic parameters

Triple-negative breast cancers are a poor prognostic group of breast cancers that don’t respond to conventional hormonal and her2neu targeted therapy. A subset of triple-negative breast cancer is known to over...

Authors: Atif Ali Hashmi, Samreen Naz, Shumaila Kanwal Hashmi, Muhammad Irfan, Zubaida Fida Hussain, Erum Yousuf Khan, Huda Asif and Naveen Faridi

miRNAs 144-3p, 34a-5p, and 206 are a useful signature for distinguishing uterine leiomyosarcoma from other smooth muscle tumors

Leiomyosarcoma (LMS) is a rare uterine neoplasm that has a high mortality rate and no specific treatment. The origin of LMS remains unknown; although, it is hypothesized that LMS arises from the malignant tran...

Authors: Beatriz Nunes Schiavon, Katia Candido Carvalho, Cláudia Malheiros Coutinho-Camillo, Glauco Baiocchi, Renan Valieris, Rodrigo Drummond, Israel Tojal da Silva, Louise De Brot, Fernando Augusto Soares and Isabela Werneck da Cunha

Columnar cell lesions of the breast: a practical review for the pathologist

Columnar cell lesions (CCLs) of the breast are characterized by the substitution of regular layer of cuboid epithelial by columnar cells covering the terminal duct lobular units (TDLUs). It also comprises a sp...

Authors: Angela Flavia Logullo and Cristiane Nimir

Mucosal Schwann cell hamartomas do occur the gastric mucosa – report of two cases mimicking fundic gland polyps

Mucosal Schwann cell hamartomas (MSCHs) are recently characterized benign spindle cell lesions of the colon and rectum. There is only one report of MSCHs in the stomach (antrum). Herein, we present the first r...

Authors: Márcia Helena Oliveira Castro, Rodrigo Jose Felipe, Amanda Fernandes Cardoso, Carlos Leonardo Martins Guimarães, Paulo Roberto Fontes Athanazio and Daniel Abensur Athanazio

Identification and immunophenotype of abnormal cells present in focal cortical dysplasia type IIb

Focal cortical dysplasias (FCDs) are malformations of cortical development that present cortical dyslamination and abnormal cell morphology and are frequently associated with refractory epilepsy. FCD type IIb ...

Authors: Gleice K. Sousa, Caroline S. Capitelli, Thaís C. D. Dombroski, César A. B. Zanella, Vera C. Terra, Tonicarlo R. Velasco, Hélio R. Machado, João A. Assirati, Carlos G. Carlotti, Vani M. Alves, Jaderson Costa DaCosta, André L. Palmini, Eliseu Paglioli, Americo C. Sakamoto, Roberto Spreafico, Rita Garbelli…

The papilla as a biomarker in the molecular era of bladder oncology

Conventional optical microscopy has been fundamental in the diagnosis of cancer for over a century. Tumor morphology has prognostic value and impact on treatment choice, but integration with molecular knowledg...

Authors: Luciana Schultz

Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy

Chronic Chagas cardiomyopathy (CCC) is characterized by the presence of a multifocal inflammatory response and myocardial damage, leading to fibrosis, arrhythmias and ventricular dysfunction. The expression of...

Authors: Ticiana Ferreira Larocca, Bruno Solano de Freitas Souza, Carolina Thé Macêdo, Carine Machado Azevedo, Juliana Fraga Vasconcelos, Daniela Nascimento Silva, Diogo Crispim Nascimento Portella, Washington Luis Conrado dos Santos, Fabio Rocha Fernandes Tavora, João David de Souza Neto, Ricardo Ribeiro dos Santos and Milena Botelho Pereira Soares

KIT exon 11 and PDGFRA exon 18 gene mutations in gastric GIST: proposal of a short panel for predicting therapeutic response

GIST is the most common mesenchymal tumor of gastrointestinal tract and is more frequent in stomach. Its main mutations affect KIT and PDGFRA genes. Full genetic analysis panels are currently used to study mutati...

Authors: Denise Barcelos, Ricardo Artigiani Neto, Leonardo Cardili, Mariana Fernandes, Fernando Cintra Lopes Carapeto, Andréia Neves Comodo, Karina Funabashi and Edna Sadayo Miazato Iwamura

Evaluation of aortic changes in elderly people autopsied with acquired immunodeficiency syndrome

To verify the distribution of the degree of fat deposits and percentage of collagen and elastic fibers in the intimal and medial layers of the aorta of elderly patients autopsied, with and without Acquired Imm...

Authors: Mariana Silva Oliveira, Bianca Gonçalves Silva Torquato, Luciano Alves Matias da Silveira, Gabriela Ribeiro Juliano, Laura Sanches Aguiar, Guilherme Ribeiro Juliano, Lívia Ferreira Oliveira, Ana Paula Espindula, Luciana Santos Ramalho, Camila Lourencini Cavellani, Aline Cristina Souza da Silva, Grace Kelly Naves de Aquino Favarato, Vicente de Paula Antunes Teixeira and Mara Lúcia da Fonseca Ferraz

Ileal Dieulafoy Lesion: a rare case report

Dieulafoy lesion, also known as calibre persistent artery is a rare cause of massive GI bleeding. It’s an abnormal sub-mucosal artery protruding from a minute mucosal defect (≤3 mm). Commonest location is in p...

Authors: Aleena Jain, Manjusha Karegar, Amita Joshi and Amey Rojekar

Introducing Surgical and Experimental Pathology

Authors: Fernando Soares

Pulmonary mucinous adenocarcinomas: a clinicopathologic series with emphasis on the prognostic significance of spread through alveolar spaces, and presence of solid growth component

Mucinous adenocarcinoma is often considered a relatively poor prognostic group among adenocarcinomas of the lung and has a high rate of pulmonary recurrence. Pathologic parameters predicting poor outcome have ...

Authors: Adina Paulk, Fabio Tavora and Allen Burke

Current topics on prostate and bladder pathology

This review addresses current issues from the daily practice of prostate and bladder diagnostic pathology.

Authors: Daniel Abensur Athanazio and Vinicius Carrera Souza

Usefulness of IMP3 and FOXP3 to predict metastasis of cutaneous melanomas

Melanoma still has considerable mortality in spite of improvements in diagnosis and treatment. Unfortunately, current diagnostic procedures cannot predict precisely its biological behavior, what urges speciali...

Authors: Juliana Polizel Ocanha-Xavier, José Cândido C. Xavier-Junior and Mariângela Esther Alencar Marques