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Upfront surgical resection for primary bone tumors: rationale and potential benefits

Abstract

Local control for the treatment of primary bone tumors is generally delayed following neoadjuvant chemotherapy. This was born out of the historical need to manufacture custom implants when performing limb-salvage resection. There is increasing reason to reconsider the timing of local control in the setting of primary bone tumors. In this report, we describe two cases in which upfront surgery was utilized and review rationale, prior literature, and potential benefits of this approach.

Introduction

Primary bone tumors, such as osteosarcoma and Ewing’s sarcoma, are traditionally treated with neoadjuvant chemotherapy followed by surgical resection and subsequent adjuvant chemotherapy (Rosen et al., 1979). The rationale to postpone local control was born out of necessity. Once limb-salvage surgery became oncologically acceptable, megaprostheses were used to reconstruct skeletal defects following tumor extirpation. Historically, these implants were custom made and required a few months’ time for their design and manufacture. Despite the subsequent development of off-the-shelf modular prosthetic systems, the practice has persisted to date. This has been attributed to several other factors, including the ability to evaluate tumor response to chemotherapy, the early systemic treatment of micro-metastatic disease, as well as the ability to develop a rapport with patients and their family prior to undertaking a life-altering surgery.

Despite this prescribed approach, the need to postpone local control is substantially diminishing. Many implants no longer require custom fabrication. The importance and impact of tumor necrosis on treatment is currently unclear, and first line therapy is generally considered the most effective approach at this junction (Bacci et al., 2003).

In some cases, upfront surgery may even offer tangible benefits. For example, there are rare primary bone tumors, which do not neatly fit within the histologic classification schema and which pose real diagnostic challenges. In such instances, sample error must be considered and larger, sometimes much larger, biopsies are needed to arrive at a diagnosis. Knowing this, upfront surgery may be preferred, in that it offers the entire lesion for histopathologic analysis and increases the confidence in any subsequent treatment recommendation. In addition, there are a number of theoretical benefits that may merit consideration as well.

In this report, we present two cases in which upfront surgery was utilized. One patient was ultimately diagnosed with a pleomorphic rhabdomyosarcoma of bone (PRMS-B) and another patient with an undifferentiated pleomorphic sarcoma of bone (UPS-B). Both patients presented as diagnostic dilemmas and were indicated for upfront local control to aid in both the diagnosis as well as their subsequent management.

Case presentations

Patient 1

A 39-year-old male presented in May 2017 with several months of right knee pain. On exam he was tender to palpation at the proximal medial tibia and exhibited soft-tissue fullness in the area of concern. The patient retained full active range of motion of the knee and was neurovascularly intact.

A right knee radiograph demonstrated an eccentric, primarily lytic lesion at the proximal medial tibial epiphysis with cortical irregularity (Fig. 1). Magnetic resonance imaging demonstrated a sharply marginated marrow-replacing lesion extending distally from the articular surface and measuring approximately 11 cm in its longest dimension (Fig. 2). The lesion appeared dark on T1-weighted MRI sequences. On T2-weighted MRI sequences the lesion appeared heterogeneous in signal intensity. Post-contrast imaging revealed avid peripheral enhancement with central non-enhancement. Cortical thinning, bone destruction and a soft-tissue component were readily apparent. The patient underwent a chest CT and PET scan for further staging workup, both of which failed to demonstrate overt metastatic disease.

Fig. 1
figure1

a Anteroposterior and b lateral radiographs of the right knee in a 39 year-old male showing an eccentric lytic lesion in the proximal tibia with associated periosteal reaction

Fig. 2
figure2

a Coronal Proton Density b Coronal T2-weighted fat-suppression c Sagittal proton density d Sagittal T2 -weighted fat-suppression magnetic resonance images of a right knee in a 39 year-old male demonstrating a well-circumscribed marrow-replacing lesion within the proximal tibia that extends from the articular surface distally. An associated periosteal reaction is evident as well as cortical thinning and destruction. There is also a soft-tissue component to the mass that extends anteromedially

His case was presented to the institutional multi-disciplinary orthopedic oncology tumor board and recommendations were to proceed with an open biopsy of the proximal tibia, which ensued uneventfully. Biopsy results demonstrated the tumor to be composed of undifferentiated round, epitheliod, spindled and pleomorphic cells with rhabdomyoblastic differentiation. Immunohistochemistry revealed positive staining for desmin (Fig. 3), indicative of muscle differentiation, as well as CD99, CD68 and focally positive for Myo-D1. Staining was negative for EMA, CD34, SMA, S100 and WT-1. The differential diagnosis included a dedifferentiated chondrosarcoma versus a primary rhabdomyosarcoma of bone.

Fig. 3
figure3

a Photomicrograph demonstrating hypercellularity (× 10, H&E) b Photomicrograph demonstrating rhabdomyoblasts with pleomorphic nuclei (× 40, H&E) c Immunohistochemical staining positive for desmin, indicative of muscle differentiation

His case was again presented at the institutional multi-disciplinary tumor board. Given the diagnostic uncertainty recommendations were to proceed with wide resection and reconstruction, deferring systemic therapy for the time.

Following resection, histologic evaluation supported the diagnosis of a primary pleomorphic rhabdomyosarcoma of bone (PRMS-B). Thereafter, he was indicated for systemic chemotherapy. At his most recent follow-up at 2 years post-operatively, he presented with recurrent pain in the knee. An infectious workup was negative, however radiographs and MRI revealed signs of component loosening. He underwent a revision procedure and has been doing well since, with no evidence of local recurrence or metastatic disease.

Patient 2

A 52-year-old female presented in September 2017 for evaluation of a left distal femur bone lesion. Her history was notable for a prior diagnosis of a benign bone lesion treated in the same location approximately 11 years earlier for which she underwent curettage and bone grafting abroad.

The patient developed recurring left knee pain, including rest pain, which began several months prior to her presentation. On exam, she exhibited a well-healed lateral surgical scar over the distal femur. She was exquisitely tender to palpation over the lateral femoral condyle and had a mild effusion. She tolerated active and passive flexion from 0 to 90 degrees, thereafter limited by pain. She was neurovascularly intact distally.

Plain radiographs demonstrated a mixed sclerotic and lucent lesion within the lateral femoral condyle (Fig. 4). Magnetic resonance imaging revealed a large mass replacing the entirety of the lateral femoral condyle, crossing midline and encroaching upon the medial femoral condyle (Fig. 5). The lesion was dark on T1-weighted images and bright on T2-weighted images. Post-contrast fat suppressed T1-weighted images demonstrated central non-enhancement with extensive enhancement in the remainder of the tumor. Comparison of advanced imaging confirmed interval enlargement relative to prior imaging obtained a few months earlier. Further imaging was obtained including a bone-scan, chest CT, and PET scan all of which failed to demonstrate metastatic disease.

Fig. 4
figure4

a Anteroposterior and b lateral radiographs of the left knee in a 52 year old female showing a mixed sclerotic and lucent lesion within the lateral femoral condyle

Fig. 5
figure5

a Coronal T1 b Coronal T2 c Sagittal T1 d Sagittal T1 fat-suppression C+ magnetic resonance images of a left knee in a 52 year old female. A large mass within the lateral femoral condyle that crosses the midline to involve the medial femoral condyle is demonstrated. There is soft tissue extension at the lateral femoral condyle with large areas of enhancing tumor within the soft tissue. Furthermore, areas of markedly low T1 and T2 signal in the lateral femoral condyle validate history of prior curettage and packing in the area

Her case was presented to the institutional multi-disciplinary orthopedic oncology tumor board and recommendations were to proceed with an open biopsy of the distal femur. Histologic findings were most supportive of a high-grade spindle cell tumor compatible with undifferentiated pleomorphic sarcoma of bone (Fig. 6). Her case was again discussed and given the unusual presentation and progression of her tumor, upfront surgery was recommended to ensure proper diagnosis and to guide subsequent recommendations. She underwent wide excision and reconstruction uneventfully.

Fig. 6
figure6

a Clinical photograph of resected tumor b Photomicrograph demonstrating hypercellularity and fibrous stroma (× 10, H&E) c Photomicrograph demonstrating spindle shaped, pleomorphic nuclei (× 40, H&E)

Final pathology confirmed the initial diagnosis of undifferentiated pleomorphic sarcoma of bone and she was subsequently started on systemic therapy in accordance with the EUROBOSS protocol. The patient completed several cycles of treatment, but was unable to tolerate the associated toxicities and elected thereafter to discontinue further treatment. At 15 months post-operatively, she presented with complaints of global discomfort in the left knee. Initial concerns for septic loosening were ruled out after joint aspiration was negative for infection. A revision procedure was done to replace the loose femoral component and to resurface the patella which exhibited moderate wear. Early results have been excellent, with pain relief and improved function. She remains well with no evidence of local recurrence or metastatic disease.

Discussion

Prior to the widespread adoption of treating primary bone tumors with neo-adjuvant chemotherapy followed by surgical resection and adjuvant therapy, the timing of surgery has not been extensively investigated or discussed. Today, custom prostheses are readily available for use almost immediately and are rarely a reason for delay of local control. Furthermore, recent EURAMOS-1 results have shown that the ability to improve osteosarcoma outcomes by the addition of cytotoxic agents has not born out (Bielack et al., 2015; Marina et al., 2016; Whelan et al., 2015). As such, the utility of and need for tumor necrosis may be less relevant than previously thought and perhaps timing of surgery in select scenarios should be reconsidered.

In this report, upfront surgery was used to affirm the diagnosis and ensure appropriate therapy. While use of neoadjuvant chemotherapy is widely agreed upon, its earlier purpose and rationale often no longer applies, particularly within the context of osteosarcoma (Bacci et al., 2003). Furthermore, despite the historical evolution of delayed local control, upfront surgical resection offers a number of theoretical advantages.

Firstly, approximately 20 % of patients with primary bone tumors present with truly localized disease; that is without disseminated micro-metastatic disease. Some of these patients will ultimately fail first-line chemotherapy, relapse, or otherwise exhibit a chemo-resistant tumor. In theory, upfront surgery offers these patients a cure.

Secondly, while oncologic outcomes remain paramount, functional outcomes need to be considered as well. Patients, relatives and surgeons are increasingly expecting more of the limb-salvage surgery and its subsequent reconstruction. Currently, patients who undergo surgery do so in a substantially deconditioned state. They oftentimes maintain non-weight bearing precautions, use crutches or other assistive devices and minimize any meaningful activity for the approximate 10-week period preceding local control. Additionally, they undergo treatment with cytotoxic chemotherapy and in turn, oftentimes remain sedentary for long periods of time during which they lose muscle mass. Their nutritional intake suffers and they often develop abnormal gait patterns. Upfront surgery, which would subject patients to surgery at a time of peak health, may result in preserved conditioning and muscle mass, and should allow for faster rehabilitation. In the absence of cytotoxic chemotherapy, healing may be more reliable and rapid. The need for assistive devices and weight bearing precautions would be minimized. In theory, all of these advantages should culminate in improved functional outcomes.

Thirdly, it remains critically important that adequate tumor samples be obtained and banked for basic and translational research. While small biopsies can be cultured, expanded, and even passaged within preclinical models, these techniques have inherent limitations. Some researchers feel that as these tumors are artificially stressed and manipulated, they evolve and mutate further, drifting substantially from their initial tumor biology. Upfront surgery offers the opportunity to secure bulk primary tumor for research, which hopefully results in improved tumorigenic understanding. At this point, it seems that only through deliberate efforts to bolster and support translational research that rationally designed therapeutics and incrementally improved outcomes can be realized.

Upfront surgery is hardly a new concept and to date, it has been explored or adopted in a number of preclinical and clinical settings. Bell et al. utilized a murine osteosarcoma model to evaluate the impact of surgical timing with respect to chemotherapy. The authors characterized mean survival, incidence of lung metastases and systemic relapse between four groups. They compared the effects of surgery alone, surgery plus preoperative chemotherapy, surgery plus post-operative chemotherapy, and surgery plus peri-operative chemotherapy. They found no significant differences between the pre-operative and post-operative chemotherapy groups in all categories (Bell et al., 1988). Goorin et al. randomly assigned 100 patients with non-metastatic osteosarcoma to receive either immediate surgery with post-operative chemotherapy or delayed surgery following neoadjuvant chemotherapy. They found that at five years, the projected event-free survival (EFS) was 69% +/− 8% in the immediate surgery and 61% +/− 8% in the delayed surgery group (p = 0.8). They concluded that neoadjuvant chemotherapy and subsequent or delayed local control did not offer a clear advantage over upfront local control with respect to EFS (Goorin et al., 2003). Meyers et al. also found that in 279 patients with untreated localized osteosarcoma, disease-free survival was not affected by use of preoperative chemotherapy versus immediate surgery (Meyers et al., 1992). Taken together, upfront surgery seems to be, at a minimum, oncologically equivalent to delayed surgery.

Pleomorphic rhabdomyosarcoma (PRMS) is a soft-tissue tumor that affects the head and neck, genitourinary system and the extremities. These tumors are histologically defined by dedifferentiated round to spindle shaped cells with dense eosinophilic staining. This heterogeneous population of cells makes diagnosis a challenge, often requiring the use of immunohistochemistry (IHC). The presence of pleomorphic rhabdomyoblasts as well as positive IHC staining for at least one muscle-specific marker is diagnostic of PRMS (Dagher & Helman, 1999; Fletcher et al., 2006; Furlong et al., 2001; Keyhani & Booher, 1968).

It is exceptionally rare for PRMS to present as a primary bone tumor. To our knowledge, there are only 11 previously reported cases of primary rhabdomyosarcoma of bone (RMS-B) (Table 1), only two of which were diagnosed as PRMS-B (Balogh et al., 2016; Bressner et al., 2016; Hakozaki et al., 2008; Hsueh et al., 1986; Kumar et al., 2011; Lamovec et al., 1994; Lucas et al., 1996; Oda et al., 1993; Pasquel et al., 1976; Thomas et al., 2002; Wang et al., 2000). In all cases, the primary lesion originated within bone and extended into the surrounding soft tissue. Treatment strategies varied among reports, though a combination of surgery, chemotherapy and/or radiotherapy were utilized. No general consensus exists in terms of surgical timing. Admittedly, the paucity of reported cases makes it difficult to draw robust conclusions; however, reported clinical outcomes vary and do not seem to be dependent upon treatment approach.

Table 1 Reported cases of rhabdomyosarcoma of bone in the literature including treatment and outcomes

Undifferentiated pleomorphic sarcoma (UPS), previously referred to as malignant fibrous histiocytoma (MFH), is a recognized rare primary bone tumor which shares many features of osteosarcoma but lacks obvious histologic evidence of malignant bone formation. It is generally grouped and treated as an osteosarcoma. It is defined on histology by a fibrous stroma with a mixture of spindle cells, giant cells, and histiocyte-like cells (McCarthy et al., 1979; Widemann & Italiano, 2018). Given the cytologic and nuclear pleomorphism that is seen after extensive sampling and use of various diagnostic techniques, UPS is a diagnosis of exclusion (Fletcher et al., 2006).

UPS seldom presents as a primary bone tumor, however review of the literature reveals several cases describing their radiographic and histologic features (Gustafson, 1994; Kumar et al., 1990; Little & McCarthy, 1993). Treatment of UPS-B involves surgical resection, chemotherapy and/or radiation, a well-established protocol for soft tissue sarcomas (Bielack et al., 1999; Natarajan et al., 2007; Sun et al., 2017). Huvos et al. reported on 130 patients diagnosed with UPS of bone (UPS-B). All of their patients underwent surgical resection; however 66 patients were treated before 1974, when modern chemotherapy was not available at the institution. They found no significant difference in survival estimates between the pre- and post-1974 treatment groups (Huvos et al., 1985). Picci et al. reviewed 51 patients with UPS-B who were treated using standardized osteosarcoma protocols with neo-adjuvant chemotherapy, surgical resection and adjuvant chemotherapy. They found that the histologic response to neo-adjuvant chemotherapy was in many cases poor, and that a clear improvement in overall survival was not proven (Picci et al., 1997). Weiner et al. and Ozkurt et al. supported these claims, using upfront surgical resection and adjuvant chemotherapy to achieve long-term disease free survival in 3 and 14 patients with UPS-B respectively. (Ozkurt et al., 2016; Weiner et al., 1983).

Although immediate surgical resection of primary bone tumors is not currently standard of care, it does offer potential advantages. Admittedly, instances remain where it may not be the appropriate approach. For example, the tremendous soft-tissue extension of a Ewing sarcoma typically noted at presentation can recede substantially following induction chemotherapy, in turn, aiding surgical resection. In other instances, custom implants such as growing prostheses are indicated. Induction chemotherapy provides treatment during the manufacturing process, which has historically been the rationale for preoperative chemotherapy.

In summary, the previous 3 decades have demonstrated stagnant outcomes for primary bone tumors, particularly for osteosarcoma and novel or “unconventional” approaches should be strongly considered. While upfront surgery may impose a few logistical challenges on surgical schedule and surgical coordination, these can largely be met. Both preclinical and clinical data seems to support that this approach is, at a minimum, oncologically non-inferior and there are a number of theoretical and real advantages both for the patient and for the field. The two rare primary bone tumors presented in this report both obviated the need for upfront surgery given their diagnostic ambiguity and treatment challenges. Admittedly, it is difficult to extrapolate experiences with rare primary bone tumors to more commonly encountered tumors such as osteosarcoma and Ewing’s sarcoma in order to make treatment recommendations. However, they may serve as examples in which upfront surgery should be considered, and may offer broader relevance and unrealized potential. Further investigations will need to be conducted in the future to determine whether a shift in the standard treatment approach for primary bone tumors should be made. That said, careful selection and patient-specific considerations are both essential and should be weighed in the context of a multi-disciplinary team that understands the inherent challenges and benefits of each approach.

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References

  1. Bacci G et al (2003) Preoperative therapy versus immediate surgery in nonmetastatic osteosarcoma. J Clin Oncol 21(24):4662–4663

    CAS  Article  Google Scholar 

  2. Balogh P et al (2016) Primary alveolar rhabdomyosarcoma of the bone: two cases and review of the literature. Diagn Pathol 11(1):99

    Article  Google Scholar 

  3. Bell RS et al (1988) Timing of chemotherapy and surgery in a murine osteosarcoma model. Cancer Res 48(19):5533–5538

    CAS  PubMed  Google Scholar 

  4. Bielack SS et al (1999) Malignant fibrous histiocytoma of bone: a retrospective EMSOS study of 125 cases. European Musculo-skeletal oncology society. Acta Orthop Scand 70(4):353–360

    CAS  Article  Google Scholar 

  5. Bielack SS et al (2015) Methotrexate, doxorubicin, and Cisplatin (MAP) plus maintenance Pegylated interferon Alfa-2b versus MAP alone in patients with Resectable high-grade osteosarcoma and good histologic response to preoperative MAP: first results of the EURAMOS-1 good response randomized controlled trial. J Clin Oncol 33(20):2279–2287

    CAS  Article  Google Scholar 

  6. Bressner JA et al (2016) Primary rhabdomyosarcoma of the distal femoral diaphysis: a case report and review of the literature. Skelet Radiol 45(10):1391–1395

    Article  Google Scholar 

  7. Dagher R, Helman L (1999) Rhabdomyosarcoma: an overview. Oncologist 4(1):34–44

    CAS  PubMed  Google Scholar 

  8. Fletcher CD, Unni KK, Mertens F (2006) Pathology and genetics of tumours of soft tissue and bone. International Agency for Research on Cancer (IARC), Lyon

    Google Scholar 

  9. Furlong MA, Mentzel T, Fanburg-Smith JC (2001) Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. Mod Pathol 14(6):595–603

    CAS  Article  Google Scholar 

  10. Goorin AM et al (2003) Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: pediatric oncology group study POG-8651. J Clin Oncol 21(8):1574–1580

    CAS  Article  Google Scholar 

  11. Gustafson P (1994) Soft tissue sarcoma. Epidemiology and prognosis in 508 patients. Acta Orthop Scand Suppl 259:1–31

    CAS  PubMed  Google Scholar 

  12. Hakozaki M et al (2008) Primary rhabdomyosarcoma of the sacrum: a case report and review of the literature. Skelet Radiol 37(7):683–687

    Article  Google Scholar 

  13. Hsueh S, Hsih SN, Kuo TT (1986) Primary rhabdomyosarcoma of long bone. A case report. Orthopedics 9(5):705–707

    CAS  PubMed  Google Scholar 

  14. Huvos AG, Heilweil M, Bretsky SS (1985) The pathology of malignant fibrous histiocytoma of bone. A study of 130 patients. Am J Surg Pathol 9(12):853–871

    CAS  Article  Google Scholar 

  15. Keyhani A, Booher RJ (1968) Pleomorphic rhabdomyosarcoma. Cancer 22(5):956–967

    CAS  Article  Google Scholar 

  16. Kumar N et al (2011) Primary rhabdomyosarcoma of proximal tibia in an adult: a rare entity. Ind J Pathol Microbiol 54(3):653–654

    Article  Google Scholar 

  17. Kumar RV, Mukherjee G, Bhargava MK (1990) Malignant fibrous histiocytoma of bone. J Surg Oncol 44(3):166–170

    CAS  Article  Google Scholar 

  18. Lamovec J et al (1994) Primary bone sarcoma with rhabdomyosarcomatous component. Pathol Res Pract 190(1):51–60

    CAS  Article  Google Scholar 

  19. Little DG, McCarthy SW (1993) Malignant fibrous histiocytoma of bone: the experience of the New South Wales bone tumour registry. Aust N Z J Surg 63(5):346–351

    CAS  Article  Google Scholar 

  20. Lucas DR et al (1996) Primary embryonal rhabdomyosarcoma of long bone. Case report and review of the literature. Am J Surg Pathol 20(2):239–244

    CAS  Article  Google Scholar 

  21. Marina NM et al (2016) Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. Lancet Oncol 17(10):1396–1408

    Article  Google Scholar 

  22. McCarthy EF, Matsuno T, Dorfman HD (1979) Malignant fibrous histiocytoma of bone: a study of 35 cases. Hum Pathol 10(1):57–70

    CAS  Article  Google Scholar 

  23. Meyers PA et al (1992) Chemotherapy for nonmetastatic osteogenic sarcoma: the memorial Sloan-Kettering experience. J Clin Oncol 10(1):5–15

    CAS  Article  Google Scholar 

  24. Natarajan MV, Mohanlal P, Bose JC (2007) Limb salvage surgery complimented by customised mega prostheses for malignant fibrous histiocytomas of bone. J Orthop Surg (Hong Kong) 15(3):352–356

    CAS  Article  Google Scholar 

  25. Oda Y et al (1993) Primary rhabdomyosarcoma of the iliac bone in an adult: a case mimicking fibrosarcoma. Virchows Arch A Pathol Anat Histopathol 423(1):65–69

    CAS  Article  Google Scholar 

  26. Ozkurt B et al (2016) Primary malignant fibrous histiocytoma of long bones: long-term follow-up. Eklem Hastalik Cerrahisi 27(2):94–99

    Article  Google Scholar 

  27. Pasquel PM, Levet SN, De Leon B (1976) Primary rhabdomyosarcoma of bone. A case report. J Bone Joint Surg Am 58(8):1176–1178

    CAS  Article  Google Scholar 

  28. Picci P et al (1997) Neoadjuvant chemotherapy in malignant fibrous histiocytoma of bone and in osteosarcoma located in the extremities: analogies and differences between the two tumors. Ann Oncol 8(11):1107–1115

    CAS  Article  Google Scholar 

  29. Rosen G et al (1979) Primary osteogenic sarcoma: the rationale for preoperative chemotherapy and delayed surgery. Cancer 43(6):2163–2177

    CAS  Article  Google Scholar 

  30. Sun J, Zhang RM, Zheng YX (2017) En bloc resection and prosthesis implantation to treat malignant fibrous histiocytoma of the humerus. Adv Clin Exp Med 26(5):781–787

    Article  Google Scholar 

  31. Thomas F et al (2002) Primary rhabdomyosarcoma of the humerus: a case report and review of the literature. J Bone Joint Surg Am 84-A(5):813–817

    Article  Google Scholar 

  32. Wang JW, Eng HL, Huang CH (2000) Primary rhabdomyosarcoma of long bone:A case report. Clin Orthop Relat Res 377:205–209

    Article  Google Scholar 

  33. Weiner M et al (1983) Adjuvant chemotherapy of malignant fibrous histiocytoma of bone. Cancer 51(1):25–29

    CAS  Article  Google Scholar 

  34. Whelan JS et al (2015) EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment. Ann Oncol 26(2):407–414

    CAS  Article  Google Scholar 

  35. Widemann BC, Italiano A (2018) Biology and Management of Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma, and malignant peripheral nerve sheath tumors: state of the art and perspectives. J Clin Oncol 36(2):160–167

    CAS  Article  Google Scholar 

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DG, BH, RY and AC were all directly involved in the care of both patients. YZ, AS, DG, BH, RY and AC were all major contributors in writing the manuscript. JT was involved in obtaining IRB study approval. All authors read and approved the final manuscript.

Corresponding author

Correspondence to David S. Geller.

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The Albert Einstein College of Medicine Institutional Review Board reviewed this case report study and have approved it for publication [IRB # 2018–8768].

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Zvi, Y.S., Singla, A., Chou, A.J. et al. Upfront surgical resection for primary bone tumors: rationale and potential benefits. Surg Exp Pathol 3, 5 (2020). https://doi.org/10.1186/s42047-020-0057-4

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Keywords

  • Upfront surgery
  • Primary bone tumor
  • Rhabdomyosarcoma
  • Undifferentiated pleomorphic sarcoma