Table 1 Apc^Min+/− and selected related genetically altered mouse models of intestinal neoplasia

Apc ^{Min+ /−}

Small intestine > colon

Adenoma

30

Moser et al. 1990 (Moser et al., 1995)

Apc ^1638N/+

Small intestine and colon; more in colon compared to Apc^Min+/−

Adenoma, carcinoma; rarely, liver metastasis (Fodde et al., 1994)

4 (10-fold reduction over Apc^Min+/)

Fibromatosis (desmoid tumors); gastric carcinoma, duodenal adenomas, cutaneous cysts

Fodde et al. 1994 (Fodde et al., 1994)

Apc ^Δ716/+

Small intestine > colon

Adenoma

254 (10-fold increase over Apc^Min+/)

Oshima et al. 1995 (Oshima et al., 1995)

Apc ^1309/+

Small intestine

Adenoma

34

Quesada et al. 1998 (Quesada et al., 1998)

ΔN131 β-catenin

Small intestine

Adenoma

1

Polycystic kidneys

Romagnolo et al. 1999 (Romagnolo et al., 1999)

Apc ^Δ474

Small intestine > colon

Adenoma

122, small intestine; 1.4 in large intestine

Adenomas in duodenum, stomach, mammary gland

Sasai et al., 2000 (Sasai et al., 2000)

Apc ^1322T

Small intestine (location shifted towards proximal small intestine)

Adenoma, some with high grade dysplasia

192, small intestine; 2, large intestine

Gastric adenomas

Pollard et al., 2009 (Pollard et al., 2009)

Apc ^580S

Not applicable

None

None

No phenotype without further manipulation

Shibata et al., 1997 (Shibata et al., 1997)

Apc ^Δ15/+

Small intestine > colon

Adenoma, some with high grade dysplasia; adenocarcinoma

176, small intestine; 8.3, large intestine

Robanus-Maandag et al., 2010 (Robanus-Maandag et al., 2010)

FabplCre;Apc^15lox/+

Colon> small intestine

Adenoma, 17% with high grade dysplasia; adenocarcinoma (18% of lesions)

14.9, small intestine; 25.6, large intestine

Robanus-Maandag et al., 2010 (Robanus-Maandag et al., 2010)

Apc ¹⁵⁷⁶

Not applicable

None

None

Multifocal breast neoplasia, trichogenic skin tumors, osteomas mimicking Gardner syndrome

Toki et al. 2013 (Toki et al., 2013)

Apc ^Δ14/+

Distal colon and rectum

Adenomas and carcinomas (50% of lesions)

36, conventional housing; 65, specific pathogen-free conditions

Mammary gland tumors; rectal prolapse

Colnot et al. 2014 (Colnot et al., 2004)