Table 2 Tumor budding (TB) and poorly differentiated clusters (PDC) classification by both pathologists on H&E and AE1/AE3 IHC and consensus classification (n = 93)
Pathologist 1 | Pathologist 2 | Consensus | ||||
|---|---|---|---|---|---|---|
Feature | n | % | n | % | n | % |
TB – H&E | ||||||
Low (0–4 cells) | 50 | 53.8 | 50 | 53.8 | 50 | 53.8 |
Intermediate (5–9 cells) | 31 | 33.3 | 27 | 29.0 | 28 | 30.1 |
High (10 or more cells) | 12 | 12.9 | 16 | 17.2 | 15 | 16.1 |
TB – AE1/AE3 | ||||||
Low (0–4 cells) | 39 | 41.9 | 25 | 26.9 | 29 | 31.2 |
Intermediate (5–9 cells) | 30 | 32.3 | 29 | 31.2 | 24 | 25.8 |
High (10 or more cells) | 24 | 25.8 | 39 | 41.9 | 40 | 43.0 |
PDC – H&E | ||||||
Low (0–4 cells) | 52 | 55.9 | 54 | 58.1 | 53 | 57.0 |
Intermediate (5–9 cells) | 24 | 25.8 | 23 | 24.7 | 21 | 22.6 |
High (10 or more cells) | 17 | 18.3 | 16 | 17.2 | 19 | 20.4 |
PDC – AE1/AE3 | ||||||
Low (0–4 cells) | 43 | 46.2 | 42 | 45.2 | 40 | 43.0 |
Intermediate (5–9 cells) | 31 | 33.3 | 32 | 34.4 | 32 | 34.4 |
High (10 or more cells) | 19 | 20.4 | 19 | 20.4 | 21 | 22.6 |