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Table 2 Summary of the relevant morphologic, immunohistochemical, cytogenetic, molecular and clinical characteristics of apocrine carcinoma of the breast

From: Apocrine lesions of breast and invasive carcinoma with apocrine differentiation: a brief review

Morphology

Cells with distinctive margins, pink granular cytoplasm, prominent nucleoli

Apocrine markers

GCDFP-15 positive, AR positive

Receptor profile

ER negative, AR positive, Her2neu positive in 1/3 cases

Cytogenetic characteristics

Gains of 1q, 2q, 1p, 7, and 17 gains, 1p, 22q, 17q, 12q, and 16q loss.

TP53 and PIK3CA / PTEN / AKT genes

  1. GCDFP-15 (Gross cystic disease fluid protein 15), AR (Androgen receptor), ER (Estrogen receptor), Her2neu (human epidermal growth factor receptor 2, also called ERBB2).
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Surgical and Experimental Pathology

ISSN: 2520-8454

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