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Table 3 Association between BM morphological parameters and age group in 120 patients with ITP

From: Impact of reticulin stain in clinical outcome of Immune Thrombocytopenic Purpura (ITP): a pathologist perspective

  Younger than 18 years
(n = 46)
18 years or older
(n = 74)
p-value*
n % n %
Global hyperplasia 6 13.0 36 48.6  < 0.001
Megaloblasts 11 23.9 27 36.5 0.107
Eosinophilia 4 8.7 8 10.8 0.483
Lymphocytosis 12 26.1 15 20.3 0.300
Lymphoid aggregate 1 2.2 6 8.1 0.174
Plasmacytosis 12 26.1 25 33.8 0.248
Megakaryocytic series
 Hypercellularity 39 84.8 70 94.6 0.070
 Lobulated nucleus 13 28.3 22 29.7 0.516
 Micromegakaryocytes 13 28.3 33 44.6 0.054
 Grouping 22 47.8 40 54.1 0.317
 Nuclear fragmentation 16 34.8 28 37.8 0.455
 Nuclear hyperchromasia 11 23.9 15 20.3 0.400
 Moderate/severe dysplasia 24 52.2 51 68.9 0.050
Reticulin Grade 2/3 1 2.2 8 10.8 0.077
Positive hemosiderin 4 8.7 20 27.0 0.011
  1. *Statistical tests used: Chi-square and Fisher exact