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Table 1 Association between morphological parameters and evolution in 120 patients with ITP

From: Impact of reticulin stain in clinical outcome of Immune Thrombocytopenic Purpura (ITP): a pathologist perspective

  Favorable outcome (n = 89) Unfavorable outcome
(n = 31)
p-value*
n % n %
Global hypercellularity 26 29.2 16 51.6 0.022
Erythrocyte series
 Increased in number 71 79.8 22 71.0 0.220
 Delayed maturation 6 6.7 1 3.2 0.419
 Megaloblasts 26 29.2 12 38.1 0.224
Granulocytic series
 Reduced/Normal 69 77.5 19 61.3 0.066
 Delayed maturation 6 6.7 6 19.4 0.053
 Eosinophilia 7 7.9 5 16.1 0.164
Lymphoplasmacytic series
 Reduced/Normal in number 54 60.7 17 54.8 0.359
 Lymphocytosis 18 20.2 9 29.0 0.220
 Lymphoid aggregate 4 4.5 3 2.5 0.257
 Plasmacytosis 28 31.5 9 29.0 0.495
 Delayed maturation 0 0.0 2 6.5 0.065
Megakaryocytic series
 Increased in number 81 91.0 28 90.3 0.578
 Lobulated nucleus 28 31.5 7 22.6 0.242
 Micromegakaryocytes 34 38.2 12 38.7 0.562
 Grouping 45 50.6 17 54.8 0.421
 Nuclear fragmentation 33 37.1 11 35.5 0.527
 Hyperchromasia 19 21.3 7 22.6 0.534
 Moderate/intense dysplasia 50 56.2 25 80.6 0.012
Stroma
 Cytotoxicity 37 41.6 11 35.5 0.353
 Edema 35 39.3 16 51.6 0.163
 Congestion 35 39.3 15 48.4 0.251
Reticulin Grade 2/3 4 4.5 5 16.1 0.049
Positive hemosiderin 17 19.1 7 22.6 0.428
Myelogram
 Compromised platelet production 80 93.0 24 85.7 0.205
Platelet count less than 33,500 platelets/mm3 66 78.6 11 39.3  < 0.001
  1. *Statistical tests used: Chi-square and Fisher exact