Table 1 Association between morphological parameters and evolution in 120 patients with ITP
Favorable outcome (n = 89) | Unfavorable outcome (n = 31) | p-value* | |||
|---|---|---|---|---|---|
n | % | n | % | ||
Global hypercellularity | 26 | 29.2 | 16 | 51.6 | 0.022 |
Erythrocyte series | |||||
Increased in number | 71 | 79.8 | 22 | 71.0 | 0.220 |
Delayed maturation | 6 | 6.7 | 1 | 3.2 | 0.419 |
Megaloblasts | 26 | 29.2 | 12 | 38.1 | 0.224 |
Granulocytic series | |||||
Reduced/Normal | 69 | 77.5 | 19 | 61.3 | 0.066 |
Delayed maturation | 6 | 6.7 | 6 | 19.4 | 0.053 |
Eosinophilia | 7 | 7.9 | 5 | 16.1 | 0.164 |
Lymphoplasmacytic series | |||||
Reduced/Normal in number | 54 | 60.7 | 17 | 54.8 | 0.359 |
Lymphocytosis | 18 | 20.2 | 9 | 29.0 | 0.220 |
Lymphoid aggregate | 4 | 4.5 | 3 | 2.5 | 0.257 |
Plasmacytosis | 28 | 31.5 | 9 | 29.0 | 0.495 |
Delayed maturation | 0 | 0.0 | 2 | 6.5 | 0.065 |
Megakaryocytic series | |||||
Increased in number | 81 | 91.0 | 28 | 90.3 | 0.578 |
Lobulated nucleus | 28 | 31.5 | 7 | 22.6 | 0.242 |
Micromegakaryocytes | 34 | 38.2 | 12 | 38.7 | 0.562 |
Grouping | 45 | 50.6 | 17 | 54.8 | 0.421 |
Nuclear fragmentation | 33 | 37.1 | 11 | 35.5 | 0.527 |
Hyperchromasia | 19 | 21.3 | 7 | 22.6 | 0.534 |
Moderate/intense dysplasia | 50 | 56.2 | 25 | 80.6 | 0.012 |
Stroma | |||||
Cytotoxicity | 37 | 41.6 | 11 | 35.5 | 0.353 |
Edema | 35 | 39.3 | 16 | 51.6 | 0.163 |
Congestion | 35 | 39.3 | 15 | 48.4 | 0.251 |
Reticulin Grade 2/3 | 4 | 4.5 | 5 | 16.1 | 0.049 |
Positive hemosiderin | 17 | 19.1 | 7 | 22.6 | 0.428 |
Myelogram | |||||
Compromised platelet production | 80 | 93.0 | 24 | 85.7 | 0.205 |
Platelet count less than 33,500 platelets/mm3 | 66 | 78.6 | 11 | 39.3 | < 0.001 |