Fig. 1
From: Dealing with prostate cancer? Don’t let histiocytic lesions fool you!
Case 1. Prostatic adenocarcinoma associated with malakoplakia. Unifocal GG2 adenocarcinoma merging a solid lesion (a HE, 40x). Detail of well differentiated glands of predominant Gleason pattern 3 (b HE, 400x) and poorly formed glands (c HE, 400x). A photomicrograph show a predominant solid lesion with an adenocarcinoma focus in the bottom (d HE, 40x). At higher magnification, transition between adenocarcinoma and solid lesion with histiocytoid appearance (e HE, 100x). Round basophilic inclusions are readily identified in HE stain within the cytoplasm of histiocytes (f HE, 400x). PAS stain in the transition zone highlights strong staining in malakoplakia (g PAS, 100x). Round inclusions (Michaelis–Gutmann bodies) are strongly positive by von Kossa stain (h von Kossa, 400x)