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Table 5 Mean p16 expression (mean H-score) and complete loss of p16 expression in urothelial carcinoma

From: Prognostic significance of p16 immunohistochemical expression in urothelial carcinoma

Clinicopathologic features Mean ± SD P-Value Complete Loss of p16 expression
n (%)
Overall 64.61 ± 93.13   33 (27.3)
 Gender
  Male 64.23 ± 92.46 0.942 23 (19)
  Female 65.63 ± 96.34 10 (8.26)
 Age group
  26–50 years 59.34 ± 73.78 0.707 5 (4.13)
  > 50 years 66.87 ± 99.13 28 (23.14)
 Tumor grade
  Low grade 26.93 ± 38.96 0.000 18 (14.87)
  High grade 105.55 ± 115.48 15 (12.39)
 Muscularis propria Invasiona
  Can’t assessed 46.97 ± 77.86 0.000 14 (11.57)
  Present 156.80 ± 124.37 4 (3.30)
  Absent 43.96 ± 68.23 15 (12.39)
 Lamina propria Invasion
  Present 131.30 ± 120.79 0.000 8 (6.61)
  Absent 39.61 ± 65.40 25 (20.66)
 Recurrence (n = 54)
  Yes 85.21 ± 107.69 0.287 4 (3.30)
  No 56.29 ± 89.59 8 (6.61)
 Survival Status (n = 54)
  Alive 51.33 ± 85.37 0.003 12 (9.91)
  Died of disease 155.00 ± 114.94 0 (0)
  1. Independent t test was applied
  2. aANOVA was applied
  3. P-Value≤0.05, considered as significant