Table 2 Genotypic analysis of the tag SNPs in the IL17A and IL17RA gene in the addictive model
Gene and reference SNPa Variation [1/2] | Groups | Homozygous 1/1 | Heterozygous 1/2 | Homozygous 2/2 | p-value* |
|---|---|---|---|---|---|
IL17A | GG | GA | AA | ||
rs3819025 [G/A] | Pandemic H1N1 | N/A | 2 (20.0) | 8 (80.0) | |
Non-pandemic | 1 (3.3) | 7 (23.3) | 22 (73.3) | 0.587 | |
Control | 1 (3.3) | 28 (93.3) | 1 (3.3) | 0.001 | |
IL17A | GG | GA | AA | ||
rs2275913 [G/A] | Pandemic H1N1 | 5 (50.0) | 4 (40.0) | 1 (10.0) | |
Non-pandemic | 7 (25.9) | 7 (25.9) | 13 (48.2) | 0.055 | |
Control | 9 (31.0) | 19 (65.5) | 1 (3.5) | 0.548 | |
IL17RA | AA | AC | CC | ||
rs2241044 [A/C] | Pandemic H1N1 | N/A | 1 (11.1) | 8 (88.9) | |
Non-pandemic | 1 (3.5) | 19 (65.5) | 9 (31.0) | 0.012 | |
Control | 3 (10.0) | 26 (86.7) | 1 (3.3) | 0.001 | |
IL17RA | TT | TC | CC | ||
rs9606615 [T/C] | Pandemic H1N1 | 3 (30.0) | 7 (70.0) | N/A | |
Non-pandemic | 4 (13.8) | 12 (41.4) | 13 (44.8) | 0.027 | |
Control | 4 (13.3) | 8 (26.7) | 18 (60.0) | 0.01 | |
IL17RA | AA | AG | GG | ||
rs2241049 [A/G] | Pandemic H1N1 | 4 (57.1) | 3 (42.9) | N/A | |
Non-pandemic | 17 (63.0) | 10 (37.0) | N/A | 0.778 | |
Control | 6 (20.0) | 21 (70.0) | 3 (10.0) | 0.054 | |
IL17RA | TT | TC | CC | ||
rs917864 [T/C] | Pandemic H1N1 | 3 (30.0) | 5 (50.0) | 2 (20.0) | |
Non-pandemic | 2 (8.3) | 12 (50.0) | 10 (41.7) | 0.102 | |
Control | N/A | 9 (30.0) | 21 (70.0) | 0.005 | |
IL17RA | CC | CT | TT | ||
rs879577 [C/T] | Pandemic H1N1 | 3 (30.0) | 7 (70.0) | N/A | |
Non-pandemic | 3 (16.7) | 15 (83.3) | N/A | 0.416 | |
Control | 21 (75.0) | 4 (14.3) | 3 (10.7) | 0.157 | |
IL17RA | CC | CT | TT | ||
rs2241043 [C/T] | Pandemic H1N1 | 1 (10.0) | 1 (10.0) | 8 (80.0) | |
Non-pandemic | 15 (71.4) | 1 (4.8) | 5 (23.8) | 0.005 | |
Control | 6 (20.7) | 22 (75.9) | 1 (3.5) | 0.001 |