From: Monocytosis and Multiple Myeloma: treatment-related acute leukaemia?
Year | Articles | Type | Focus | Patients | Sex | Age | Plasma Cell Dyscrasia | Ig | Alkylating agents | Vinca alkaloids | Others | Symptoms/signs | Cytopenia | Monocytosis | Follow up |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1966 | Nordensson | monocytic | simultaneous | 7/310 | MM | CPM, MPN | VCR | ||||||||
1969 | Poulik | monocytic | simultaneous | gammopathy | |||||||||||
1974 | Osserman | monomyelocytic | therapy-associated | M | 45 | MM | MPN | Rxtx, urethane | lysozyme nephropathy | no | deteriorated | ||||
1974 | Osserman | monomyelocytic | therapy-associated | F | 41 | MM | IgG | MPN | hormonals | fever; lysozyme nephropathy | yes | deteriorated | |||
1974 | Osserman | monomyelocytic | therapy-associated | M | 28 | MM | CPM, MPN | hormonals | fever, lysozyme nephropathy | yes | deteriorated | ||||
1974 | Marcovic | monocytic | therapy-associated | M | 48 | MM | IgGK | MPN | WL, back pain, fatigue, pallor, n/v | anemia | yes | died | |||
1979 | Bierbach | monocytic | therapy-associated | 3/100 | MM | MPN | Rxtx | ||||||||
1982 | Naparstek | monocytic | simultaneous | M | 68 | PCD, leukemic phase | IgGK | CPM, MPN | VCR | biodegradable 1,3-bis(chloro-ethyl)-1-nitrosourea | weakness, pallor, hepatosplenomegaly | bicytopenia | yes | died | |
1984 | Raz | monoblastic | simultaneous | M | 68 | MM | IgGK | MPN | pallor, hepatosplenomegaly | bicitopenia | yes | died | |||
1984 | Raz | monoblastic | simultaneous | M | 60 | MM | IgA | pallor, hepatosplenomegaly | anemia | yes | deteriorated | ||||
1989 | Abe | monocytic | therapy-associated | MM | |||||||||||
2002 | Levinson | monocytic | simultaneous | M | 83 | SMM | IgGL | dysuria | anemia | yes | |||||
2003 | Luca | monocytic | simultaneous | M | 77 | MM | IgGL | diaphoresis, WL, juandice, hip pain | anemia | yes | deteriorated | ||||
2014 | Muruktla | monoblastic | simultaneous | F | 66 | MM | IgGK | fatigue, WL | anemia | yes | died | ||||
2015 | Shi | monocytic | simultaneous | M | 78 | MM | IgML | CPM | Thal | n/a | n/a | n/a | relapsed |