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Table 5 Correlation between clinicopathological parameters at diagnosis and intratumor staining for TGFβ1 components according to p53 status

From: TGFβ1 pathway components in breast cancer tissue from aggressive subtypes correlate with better prognostic parameters in ER-positive and p53-negative cancers

p53 status

Parameter

Correlation with clinicopathological feature [Tau (p)]

TGFβ1

TGFβRII

p-SMAD2/3

p53-negative

Age

0.144 (0.357)

0.104 (0.522)

0.116 (0.473)

Tumor size

−0.490 (0.018)*

−0.500 (0.019)*

−0.431 (0.036)*

Hist. grade

−0.024 (0.933)

0.071 (0.784)

0.095 (0.712)

Ki67

−0.568 (0.000)*

−0.479 (0.007)*

− 0.462 (0.004)*

LNM

−0.237 (0.485)

−0.189 (0.568)

− 0.284 (0.400)

Stage

0.053 (0.864)

0.160 (0.586)

0.094 (0.686)

p53-positive

Age

−0.183 (0.209)

−0.160 (0.342)

− 0.190 (0.233)

Tumor size

−0.087 (0.637)

0.033 (0.868)

−0.040 (0.840)

Hist. grade

−0.199 (0.253)

−0.100 (0.576)

− 0.191 (0.269)

Ki67

0.332 (0.194)

0.399 (0.117)

0.355 (0.167)

LNM

0.199 (0.444)

0.111 (0.687)

0.111 (0.677)

Stage

−0.216 (0.288)

−0.116 (0.584)

− 0.191 (0.336)

  1. *Significant correlation (p < 0.05)