Table 4 Correlation between clinicopathological parameters at diagnosis and intratumor staining for TGFβ1 components according to evaluated breast cancer subtypes
Subtype | Parameter | Correlation with clinicopathological feature [Tau (p)] | ||
|---|---|---|---|---|
TGFβ1 | TGFβRII | p-SMAD2/3 | ||
General BC | Age | −0.014 (0.879) | −0.056 (0.585) | 0.038 (0.735) |
Tumor size | −0.206 (0.133) | −0.173 (0.243) | − 0.146 (0.302) | |
Hist. grade | 0.189 (0.139) | −0.099 (0.458) | −0.078 (0.549) | |
Ki67 | −0.116 (0.438) | −0.082 (0.556) | − 0.085 (0.557) | |
p53 | 0.020 (0.924) | 0.051 (0.804) | −0.012 (0.955) | |
LNM | −0.031 (0.876) | −0.078 (0.585) | − 0.068 (0.641) | |
Stage | −0.072 (0.644) | −0.018 (0.907) | − 0.042 (0.771) | |
LB-HER2+ | Age | 0.377 (0.085) | 0.353 (0.102) | 0.551 (0.004)* |
Tumor size | −0.444 (0.004)* | −0.592 (0.001)* | − 0.167 (0.571) | |
Hist. grade | 0.185 (0.596) | 0.148 (0.602) | 0.407 (0.135) | |
Ki67 | −0.333 (0.194) | −0.296 (0.141) | − 0.111 (0.453) | |
p53 | −0.563 (0.109) | −0.563 (0.063) | − 0.813 (0.001)* | |
LNM | −0.593 (0.052) | −0.593 (0.052) | − 0.691 (0.007)* | |
Stage | −0.243 (0.489) | −0.296 (0.427) | − 0.259 (0.303) | |
HER2 | Age | −0.085 (0.746) | −0.141 (0.483) | − 0.085 (0.658) |
Tumor size | −0.148 (0.700) | −0.074 (0.806) | − 0.074 (0.806) | |
Hist. grade | −0.296 (0.396) | −0.099 (0.773) | − 0.198 (0.559) | |
Ki67 | 0.296 (0.423) | 0.198 (0.648) | 0.198 (0.648) | |
p53 | 0.000 (1.000) | 0.000 (1.000) | 0.000 (1.000) | |
LNM | 0.000 (1.000) | −0.198 (0.608) | −0.099 (0.800) | |
Stage | −0.165 (0.573) | 0.033 (0.921) | −0.033 (0.919) | |
TN | Age | −0.192 (0.098) | −0.226 (0.104) | − 0.226 (0.081) |
Tumor size | 0.154 (0.492) | 0.120 (0.620) | 0.068 (0.771) | |
Hist. grade | −0.016 (0.955) | 0.102 (0.643) | 0.047 (0.865) | |
Ki67 | 0.059 (0.805) | 0.000 (1.000) | 0.000 (1.000) | |
p53 | 0.284 (0.303) | 0.356 (0.177) | 0.284 (0.303) | |
LNM | 0.141 (0.629) | 0.047 (0.870) | 0.047 (0.871) | |
Stage | 0.199 (0.377) | 0.199 (0.321) | 0.129 (0.541) | |