Table 3 Correlation between TGFB1 and TGFBR2 SNPs TGFβ1 components staining
Variant | Modela | Correlation with genetic variant [Tau-c (p)] | ||
|---|---|---|---|---|
TGFβ1 | TGFβRII | p-SMAD2/3 | ||
TGFBR2 G-875A (rs3087465) | Additive | −0.127 (0.456) | −0.138 (0.399) | −0.151 (0.327) |
Dominant | −0.183 (0.357) | − 0.211 (0.279) | − 0.194 (0.321) | |
Recessive | 0.021 (0.877) | 0.042 (0.733) | −0.028 (0.787) | |
TGFB1 G-800A (rs1800468) | Dominant | 0.066 (0.549) | 0.107 (0.301) | 0.031 (0.684) |
TGFB1 C-509T (rs1800469) | Additive | 0031 (0.820) | 0.005 (0.971) | 0.013 (0.927) |
Dominant | −0.028 (0.802) | − 0.007 (0.955) | − 0.010 (0.930) | |
Recessive | 0.055 (0.765) | 0.014 (0.940) | 0.035 (0.851) | |
TGFB1 T29C (rs1800470) | Additive | −0.096 (0517) | −0.153 (0.300) | − 0.093 (0.513) |
Dominant | −0.121 (0.289) | −0.183 (0.121) | − 0.128 (0.231) | |
Recessive | −0.066 (0.737) | −0.093 (0.627) | − 0.028 (0.886) | |
TGFB1 G74C (rs1800471) | Additive | −0.026 (0.792) | −0.067 (0.513) | − 0.057 (0.552) |
Dominant | −0.048 (0.727) | −0.104 (0.480) | − 0.090 (0.514) | |
Recessive | 0.055 (0.334) | 0.021 (0.714) | 0.000 (1.000) | |
TGFB1 GCTG haplotype | Additive | −0.075 (0.596) | −0.039 (0.787) | 0.000 (1.000) |
Dominant | −0.104 (0.606) | −0.090 (0.651) | − 0.038 (0.849) | |
Recessive | 0.003 (0.959) | 0.059 (0.459) | 0.073 (0.364) | |
TGFB1 GTCG haplotype | Additive | −0.096 (0.477) | −0.127 (0.359) | − 0.062 (0.662) |
Dominant | −0.145 (0.300) | −0.131 (0.372) | − 0.066 (0.637) | |
Recessive | −0.045 (0.790) | −0.087 (0.602) | − 0.031 (0.861) | |