Table 2 Characteristics of studies included in this review
Author | Median Age (years) | Gender | Tumor location | Breslow Thickness (mm) | Ulceration % | 1 positive SLN | SLN metastasis ≤ 1 mm | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
year | Obs. | CLND | Female | Male | Extremity | Head & neck | Trunk | Obs. | CLND | Obs. | CLND | Obs. | CLND | |
Bamboat (Bamboat et al., 2014) | 66 (8–95) | 56 (7–90) | 185 (37%) | 310 (63%) | 231 (47%) | 58 (12%) | 182 (37%) | 2.8 | 218/446 (49%) | 380 (77%) | 230 (46%) | |||
2.8 (0.7–18) | 2.8(0.7–38) | 77 (46%) | 141 (44%) | 134 (80%) | 246 (75%) | |||||||||
Satzger (Satzger et al., 2014) | 64 (10–91) | 60 (18–87) | 141 (46%) | 164 (54%) | 154(50%) | 21(7%) | 130 (43%) |  | 122 (40%) | 243 (80%) |  | |||
2.3 (1.0–13) | 2.6 (1.0–17) | 22 (38%) | 100 (40%) | 51 (88%) | 192 (78%) | |||||||||
Ploeg (van der Ploeg et al., 2014) | 52.3 ± 15.3b | 702(46%) | 837(54%) | 779(51%) | 211(14%) | 533(35%) | 2.95 (1.80–4.50) | 655/1436 (46%) | 1030 (79%) | 811(53%) | ||||
Melstrom (Melstrom et al., 2014) | 55 (19–89) | 25 (26%) | 72 (74%) | 16 (17%) | 13 (13%) | 68 (70%) | 3.2 (0.8–12) | 49 (51%) |  |  | ||||
58 (19–89) | 53 (24–77) | 4.2(1.2–10.5) | 3 (0.8–12) | 7(33%) | 42 (55%) | |||||||||
Gyorki (Gyorki et al., 2014) | 66 | 54 | 14 (26%) | 40 (74%) | 0 | 54 (100%) | 0 | 2.2 (0.9–18.0) | 2.8 (1.1–15.0) | 20 (37%) |  |  | ||
8 (44%) | 12 (33%) | |||||||||||||
Fritsch (Fritsch et al., 2016) | 58 (3–89) | 71 (20%) | 66 | 0 | 350 (100%) | 0 |  | 106 /327 (32%) |  |  | ||||
62 (3–89) | 54 (11–87) | 41 (32%) | 65 (33%) | |||||||||||
Mosquera (Mosquera et al., 2017) | 56 | 843 (39%) | 1329 (61%) | 1051 (48%) | 281 (13%) | 840 (39%) | Â | 783/2131 (36%) | 1586 (73%) | Â | ||||
59 (10–98) | 55 (2–91) | 34% (263) | 66% (520) | 590 (83%) | 996 (69%) | |||||||||
Lee (Lee et al., 2016) | 56 (7–95)a | 53 (4–98)a | 187 (40%) | 284 (60%) | 201 (43%) | 76 (16%) | 194 (41%) | 3.1 ± 2.7 b | 3.0 ± 3.6 b | 135/456 (30%) | 377 (80%) |  | ||
34 (35%) | 101 (27%) | 79 (82%) | 298 (80%) | |||||||||||
Faries (Faries et al., 2017) | 54.9 (19–76) | 53.7 (18–76) | 728 (41%) | 1027 (59%) | 709 (40%) | 241 (14%) | 805 (46%) | 2.10 (0.35–30.0) | 2.10 (0.34–28.0) | 669 (38%) | 1239/1564 (79%) | 786/1189 (66%) | ||
353 (38%) | 316 (38%) | 643 (69%) | 596 (72%) | |||||||||||
Klemen (Klemen et al., 2019) | 54.5 (42.4–66.7)a | 376 (39%) | 577 (61%) | 428 (45%) | 126 (13%) | 397 (42%) | 2.5 (1.4–4.1)a | 120 /588 (13%) |  |  | ||||
64 (51–75)a | 53.6 (41.6–65.1)a | 2.4 (1.4–4.5)a | 2.5 (1.4–4)a | 13 (11%) | 107 (13%) | |||||||||
Leiter (Leiter et al., 2019) | 54 (45–66.5)a | 182 (38%) | 291 (62%) | 226 (48%) | 0 | 247 (52%) | 2.4 (1.6–4)a | 185 (39%) | 435 (92%) | 311(66%) | ||||
56 (45–66)a | 57 (47–67.8)a | 2.4 (1.5–3.85)a | 2.4 (1.6–4)a | 95 (41%) | 90 (38%) | 213 (91%) | 222 (91%) | |||||||