Fig. 3
From: Dealing with prostate cancer? Don’t let histiocytic lesions fool you!
Prostate biopsy with a lesion of infiltrative appearance within the stroma and glandular epithelium. Morphology of these cells are reminiscent of signet ring tumor cells (HE stain: a 100x; b 400x, c 400x). Glands show preserved basal cell layer (d Cocktail P63 and high molecular weight cytokeratin 34bE12 – 400x). Signet ring-like cells do not express PSA, and negative PSA cells are seen infiltrating glandular epithelium (PSA immunohistochemistry: e 400x). Signet ring-like cells strongly express CD68 and infiltrates glandular epithelium (CD68 immunohistochemistry: f 100x, g 400x, h 400x)