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Fig. 4 | Surgical and Experimental Pathology

Fig. 4

From: Concurrent breast adenoid cystic carcinoma and primary squamous cell carcinoma: report of a rare case with single institutional case reviews

Fig. 4

Microscopic and immunohistochemical examinations for the left breast lesion. a Skin ulceration with congested blood vessels in dermis. Squamous epithelium adjacent to the ulceration appeared unremarkable. b Examination of the central cyst of the left breast lesion revealed cystic lining by squamous cell carcinoma. c Nests of squamous cell carcinoma with prominent keratinizing was noted diffusely in the lesion. d Stromal spindle cells were mixed with acute and chronic inflammatory cells. Very rare mitotic figure was noted (arrow). e Immuostains for CK5/6, f p63 and g CAM5.2 showed positivity in squamous cell carcinoma, but were are negative in the spindle cell component. h Both the squamous cell carcinoma and the spindle cell component were negative for SOX10 immunostain. (Hematoxylin-eosin, original magnification × 10 [a, b, c], 20x [d, h]; Immunohistochemistry, original magnification × 10 [e, f, g], × 20 [h])

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