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Fig. 1 | Surgical and Experimental Pathology

Fig. 1

From: Immunohistochemical expression of receptors for luteinizing hormone-releasing hormone (LHRHR) in muscle-invasive Urothelial carcinoma of urinary bladder: a potential predictive marker for targeted cytotoxic LHRH hybrid analogs

Fig. 1

Muscle invasive urothelial carcinoma. a Diffuse sheet of neoplastic cells with pleomorphic hyperchromatic nuclei, inconspicuous nucleoli and pale eiosinophilic cytoplasm (H&E, 20x);b Diffuse sheet and nest of neoplastic cells with pleomorphic vesicular nuclei, coarse nuclear chromatin, prominent nucleoli, abundant eiosinophilic cytoplasm and apoptotic debri (H&E, 20x); c: Focal (1+) and strong cytoplasmic granular LHRHR staining in tumor cells (LHRHR immunostain, 40x); d: Focal (2+) and strong cytoplasmic granular LHRHR staining in urothelial carcinoma cells (LHRHR immunostain, 20x); e: Strong membranous and granular cytoplasmic LHRHR immunostaining (3+) in urothelial carcinoma cells (LHRHR immunostain, 20x); f: Strong membranous and cytoplasmic immunostaining for LHRHR (4+) in urothelial carcinoma cells (LHRHR immunostain, 40x)

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