Fig. 1

Muscle invasive urothelial carcinoma. a Diffuse sheet of neoplastic cells with pleomorphic hyperchromatic nuclei, inconspicuous nucleoli and pale eiosinophilic cytoplasm (H&E, 20x);b Diffuse sheet and nest of neoplastic cells with pleomorphic vesicular nuclei, coarse nuclear chromatin, prominent nucleoli, abundant eiosinophilic cytoplasm and apoptotic debri (H&E, 20x); c: Focal (1+) and strong cytoplasmic granular LHRHR staining in tumor cells (LHRHR immunostain, 40x); d: Focal (2+) and strong cytoplasmic granular LHRHR staining in urothelial carcinoma cells (LHRHR immunostain, 20x); e: Strong membranous and granular cytoplasmic LHRHR immunostaining (3+) in urothelial carcinoma cells (LHRHR immunostain, 20x); f: Strong membranous and cytoplasmic immunostaining for LHRHR (4+) in urothelial carcinoma cells (LHRHR immunostain, 40x)