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Table 2 Concordance between the immunohistochemical test for translocation involving the BCL2 gene, with FISH as gold standard: comparison between 50% cut-off and 70% cut-off for definition of immunopositivity for BCL2 in immunohistochemistry

From: 50% versus 70%: is there a difference between these BCL2 cut-offs in immunohistochemistry for diffuse large B-cell lymphomas (DLBCL)?

 

Sa

Eb

PPVc

NPVd

Ae

Kappa

p-value*

Cutoff above 50%

100%

39,7%

[27,1-52,2]

20,4%

[8,5-32,4]

100%

47%

[35,8-59,7]

0,15

0,017

Cutoff above 70%

88,9%

[68,4-109,4]

67,2%

[55,2-79,3]

29,6%

[12,4-46,9]

97,5%

[92,7-102,3]

70%

[59,2-81,1]

0,30

0,002

  1. a = Sensitivity (S), b = specificity (E), c = positive predictive value (PPV), d = negative predictive value (NPV), e = accuracy (A), * = Values presented with a 95% confidence interval and a level of significance lower than 0.05