Skip to main content

Table 3 Correlations between clinicopathological features and Transgelin expression in all the included cases

From: The values of Transgelin, Stathmin, BCOR and Cyclin-D1 expression in differentiation between Uterine Leiomyosarcoma (ULMS) and Endometrial Stromal Sarcoma (ESS); diagnostic and prognostic implications

CharacteristicsAll (N = 44)Transgelin   
  Negative (N = 25)Focal weak +ve (N = 6)Diffuse strong +ve (N = 13)p-value
 No. (%)No. (%)No. (%)No. (%) 
Age (years)
 Mean ± SD56.84 ±7.9352.84 ±7.5665 ±4.9760.76 ±4.16<0.001*
 Median (Range)57 (39-72)51 (39-72)63.50 (59-72)60 (56-70) 
 ≤ 55 years18 (40.9%)18 (100%)0 (0%)0 (0%)<0.001‡
 > 55 years26 (59.1%)7 (26.9%)6 (23.1%)13 (50%) 
Histopathology
 LMS22 (50%)3 (13.6%)6 (27.3%)13 (59.1%)<0.001‡
 ESS22 (50%)22 (100%)0 (0%)0 (0%) 
Grade
 Grade I9 (20.5%)7 (77.8%)2 (22.2%)0 (0%)0.014‡
 Grade II12 (27.3%)5 (41.7%)4 (33.3%)3 (25%) 
 Grade III23 (52.3%)13 (56.5%)0 (0%)10 (43.5%) 
Extrauterine extension
 Absent6 (13.6%)5 (83.3%)1 (16.7%)0 (0%)<0.001‡
 Present9 (20.5%)4 (44.4%)5 (55.6%)0 (0%) 
 N/A29 (65.9%)16 (55.2%)0 (0%)13 (44.8%) 
LVSI
 Absent21 (47.7%)10 (47.6%)6 (28.6%)5 (23.8%)0.022‡
 Present23 (52.3%)15 (65.2%)0 (0%)8 (34.8%) 
Adnexal invasion
 Absent11 (25%)7 (63.6%)4 (36.4%)0 (0%)0.007‡
 Present33 (75%)18 (54.5%)2 (6.1%)13 (39.4%) 
Lymph node
 Negative16 (36.4%)9 (56.2%)6 (37.5%)1 (6.2%)0.001‡
 Positive28 (63.6%)16 (57.1%)0 (0%)12 (42.9%) 
FIGO Stage
 Stage I6 (13.6%)5 (83.3%)1 (16.7%)0 (0%)0.001‡
 Stage II10 (22.7%)4 (40%)5 (50%)1 (10%) 
 Stage III13 (29.5%)5 (38.5%)0 (0%)8 (61.5%) 
 Stage IV15 (34.1%)11 (73.3%)0 (0%)4 (26.7%) 
Stathmin
 Negative19 (43.2%)19 (100%)0 (0%)0 (0%)<0.001‡
 Focal weak +ve12 (27.3%)5 (41.7%)6 (50%)1 (8.3%) 
 Diffuse strong +ve13 (29.5%)1 (7.7%)0 (0%)12 (92.3%) 
BCOR
 Negative23 (52.3%)7 (30.4%)6 (26.1%)10 (43.5%)0.004‡
 Focal weak +ve7 (15.9%)5 (71.4%)0 (0%)2 (28.6%) 
 Diffuse strong +ve14 (31.8%)13 (92.9%)0 (0%)1 (7.1%) 
Cyclin-D1
 Negative24 (54.5%)5 (20.8%)6 (25%)13 (54.2%)<0.001‡
 Focal weak +ve5 (11.4%)5 (100%)0 (0%)0 (0%) 
 Diffuse strong +ve15 (34.1%)15 (100%)0 (0%)0 (0%) 
  1. * Kruskal Wallis H test; ‡ Chi-square test; p < 0.05 is significant