Clinical, pathological and prognostic implications of USP22, SIRT1 and E-cadherin expression in papillary thyroid cancer (PTC) and adjacent non-neoplastic tissue

Table 4 Correlations between USP22, SIRT1 and E-cadherin expression and outcome of PTC patients (N = 40)

	USP 22				p	SIRT1				p	E-cadherin				p
	Low		High			Low		High			Low		High
	N = 15		N = 25			N = 21		N = 19			N = 25		N = 15
Response
PD	0	0.0%	0	0.0%	0.378	0	0.0%	0	0.0%	0.564	0	0.0%	0	0.0%	0.692
SD	0	0.0%	1	4.0%		0	0.0%	1	5.3%		1	4.0%	0	0.0%
PR	0	0.0%	2	8.0%		1	4.8%	1	5.3%		1	4.0%	1	6.7%
CR	15	100.0%	22	88.0%		20	95.2%	17	89.5%		23	92.0%	14	93.3%
Overall Response
NoCR	0	0.0%	3	12.0%	0.163	1	4.8%	2	10.5%	0.489	2	8.0%	1	6.7%	0.877
CR	15	100.0%	22	88.0%	0.163	20	95.2%	17	89.5%	0.489	23	92.0%	14	93.3%	0.877
Recurrence
No	13	86.7%	7	28.0%	0.001	15	71.4%	5	26.3%	0.006	9	36.0%	11	73.3%	0.02
Yes	2	13.3%	15	60.0%	0.001	5	23.8%	12	63.2%	0.006	14	56.0%	3	20.0%	0.02
Outcome
Censored	13	86.7%	20	80.0%	0.591	19	90.5%	14	73.7%	0.163	19	76.0%	14	93.3%	0.162
Died	2	13.3%	5	20.0%	0.591	2	9.5%	5	26.3%	0.163	6	24.0%	1	6.7%	0.162

ISSN: 2520-8454