Skip to main content
Fig. 6 | Surgical and Experimental Pathology

Fig. 6

From: Epidermodysplasia verruciformis: revision of a model of carcinogenic disease

Fig. 6

Schematic representation of HPV infection and its carcinogenesis. a After breakdown the cutaneous barrier, occurs the basal cell layer infection, where the HPV remains in a latent phase as extrachromosomal plasmids. The infectious viral particles replicate in differentiated keratinocytes from the suprabasal layers. b Epithelial carcinogenesis by alpha-HPV, with integration of the viral genome into the host cell chromosomes, as observed in cervical uterine carcinogenesis. c Mechanisms on cutaneous carcinogenesis by beta-HPV, which includes telomerase activation by E6 protein, block of pro- apoptotic protein BAK and binding the XRCC1 protein, with blocks the DNA repair mechanism

Back to article page