Table 3 Correlation between PD-L1, FOXP-1 and STAT-3 expression and outcome of our patients
Characteristics | All | PD-L1 | p-value | FOXP-1 | p-value | STAT-3 | p-value | |||
|---|---|---|---|---|---|---|---|---|---|---|
Low (N = 31) | High (N = 19) |  | Low (N = 29) | High (N = 21) |  | Low (N = 27) | High (N = 23) |  | ||
(N = 50) | ||||||||||
No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | ||||
Response | ||||||||||
PD | 3 (6%) | 1 (3.2%) | 2 (10.5%) | 0.013a | 1 (3.4%) | 2 (9.5%) | 0.030a | 0 (0%) | 3 (13%) | 0.044a |
SD | 2 (10.5%) | 0 (0%) | 2 (10.5%) | 0 (0%) | 2 (9.5%) | 1 (3.7%) | 1 (4.3%) | |||
PR | 3 (6%) | 0 (0%) | 3 (15.8%) | 0 (0%) | 3 (14.3%) | 0 (0%) | 3 (13%) | |||
CR | 42 (84%) | 30 (96.8%) | 12 (63.2%) | ]28 (96.6%) | 14 (66.7%) | 26 (96.3%) | 16 (69.6%) | |||
NR | 5 (10%) | 1 (3.2%) | 4 (21.1%) | 0.062a | 1 (3.4%) | 4 (19%) | 0.148a | 1 (3.7%) | 4 (17.4%) | 0.467a |
OAR | 45 (90%) | 30 (96.8%) | 15 (78.9%) | 28 (96.6%) | 17 (81%) | 26 (96.3%) | 19 (82.6%) | |||
Relapse | (N = 42) | (N = 30) | (N = 12) | (N = 28) | (N = 14) | (N = 26) | (N = 16) | |||
Absent | 28 (66.7%) | 26 (86.7%) | 2 (16.7%) | < 0.001a | 27 (96.4%) | 1 (7.1%) | < 0.001a | 22 (84.6%) | 6 (37.5%) | 0.002a |
Present | 14 (33.3%) | 4 (13.3%) | 10 (83.3%) | 1 (3.6%) | 13 (92.9%) | 4 (15.4%) | 10 (62.5%) | |||
RFS | ||||||||||
Mean (months) | 30.11 | 33.72 | 20.35 | < 0.001b | 35.81 | 18.42 | < 0.001b | 35.81 | 18.42 | < 0.001b |
(95%CI) | (27.27–32.95) | (31.42–36.03) | (15.42–25.27) | (35.45–36.17) | (14.32–22.52) | (35.45–36.17) | (14.32–22.52) | |||
1 year RFS | 90.5% | 96.7% | 75% | 100% | 71.4% | 96.2% | 81.3% | |||
2 year RFS | 73.6% | 90% | 30% | 100% | 21.4% | 88.5% | 48.6% | |||
3 year RFS | 66.1% | 86.5% | 10% | 96.3% | 7.1% | 84.4% | 34.7% | |||
Mortality | (N = 50) | (N = 31) | (N = 19) | (N = 29) | (N = 21) | (N = 27) | (N = 23) | |||
Alive | 33 (66%) | 29 (93.5%) | 4 (21.1%) | < 0.001a | 29 (100%) | 4 (19%) | < 0.001a | 24 (88.9%) | 9 (39.1%) | < 0.001a |
Died | 17 (34%) | 2 (6.5%) | 15 (78.9%) | 0 (0%) | 17 (81%) | 3 (11.1%) | 14 (60.9%) | |||
OS | ||||||||||
Mean (months) | 29.78 | 34.77 | 21.18 | < 0.001b | 36 | 21.09 | < 0.001b | 33.92 | 24.80 | < 0.001b |
(95%CI) | (27.23–32.34) | (33.12–36.42) | (17.37–24.99) |  | (17.51–24.68) | (31.70–36.14) | (20.72–28.89) | |||
1 year OS | 92% | 100% | 78.9% | 100% | 81% | 100% | 82.6% | |||
2 year OS | 69.8% | 93.5% | 29.6% | 100% | 28.6% | 88.9% | 46.8% | |||
3 year OS | 65.7% | 93.5% | 17.8% | 100% | 19% | 88.9% | 37.5% | |||