From: Apc-related models of intestinal neoplasia: a brief review for pathologists
Feature | Favors Invasive Carcinoma | Favors Herniated Epithelium |
---|---|---|
Comparison with overlying mucosa | Invasive cells are different from overlying mucosa, with changes exceeding low grade dysplasia | Dysplasia is absent |
Desmoplasia | Present; not associated with prominent inflammatory infiltrate. | Absent; lamina propria may exhibit fibromuscular obliterative changes in prolapse |
Crypt/gland profile | Irregular, pointed, angulated crypt profiles | Rounded; may be cystically dilated |
Spread relative to mucosal surface | Invading crypts spread laterally | No lateral spread from overlying mucosa. |
Cell loss from leading edge | Present; crypts are incompletely lined by epithelium | Absent; crypts are completely lined by epithelial cells |
Number of crypts in question | More than 2 invading crypts | Two or fewer crypts in question |
Basement membrane | Discontinuous | Continuous |
Findings in other mice of the same genotype | Evidence of progression to invasive cancer in other mice | No invasive cancer in other mice |