Table 2 Apc-related models, other species

Apc^Pirc/+ (rat)

Small intestine and large intestine

Adenoma, carcinoma

Small intestine: 1.5 to 22; large intestine: 7 to 26; depending on strain and sex.

odontomas

Amos-Landgraf et al., 2007 (Amos-Landgraf et al., 2007); Irving et al. 2014 (Irving et al., 2014)

Kyoto Apc Delta (KAD) (rat)

Colon (requires AOM/DSS treatment)

Treatment with AOM/DSS induces colorectal adenocarcinoma, invasive into submucosa

9.5, males; 5.8, females

Yoshima et al., 2009 (Yoshimi et al., 2009); Irving et al. 2014 (Irving et al., 2014)

APC^1311/+ (pig)

Colon

Adenoma, some with high grade dysplasia

> 100

Flisikowska et al., 2012 (Flisikowska et al., 2012)