Fig. 9
From: Apc-related models of intestinal neoplasia: a brief review for pathologists
a Invasive carcinoma may be seen in longer-lived ApcMin/+-related models. In contrast to the smooth crypt profile of herniation, the invasive adenocarcinoma shown here has an angulated profile with infiltration of tumor cells into a desmoplastic stroma. b In this example from a Apc1638N/+ mouse, adenocarcinoma cells infiltrate the lamina propria as small angulated glands with pointed profiles and elicit an inflammatory and stromal reaction