Fig. 1

p16 expression in Urothelial carcinoma. a Complete loss of p16 expression, H-score 0; (b) Low p16 expression, weak expression (1+) in 10% of tumor cells, H-score 10 (1 × 10), (c) Low p16 expression, Intermediate expression (2+) in 25% of tumor cells, H-score 50 (2 × 25); (d) High expression p16 expression, strong expression (3+) in 95% of tumor cells, H-score 285 (3 × 95). Magnification = 400×