Table 2 Immunohistochemical features in columnar cell changes (CCC)
From: Columnar cell lesions of the breast: a practical review for the pathologist
Immunoexpression | Columnar cell change (CCC) | Flat epithelial atypia (FEA) |
|---|---|---|
ER | homogeneous | homogeneous |
PR | homogeneous | homogeneous |
Ki-67 | focally positive | focally positive |
CK19 | positive | positive |
CK5/6 | negative | negative |
Bcl-2 | positive | positive |
Cyclin D1 | focally positive | positive (5–50% cells) |