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Table 2 Immunohistochemical features in columnar cell changes (CCC)

From: Columnar cell lesions of the breast: a practical review for the pathologist

Immunoexpression Columnar cell change (CCC) Flat epithelial atypia (FEA)
ER homogeneous homogeneous
PR homogeneous homogeneous
Ki-67 focally positive focally positive
CK19 positive positive
CK5/6 negative negative
Bcl-2 positive positive
Cyclin D1 focally positive positive (5–50% cells)
  1. ER estrogen receptor, PR progesterone receptor