Fig. 4From: The papilla as a biomarker in the molecular era of bladder oncologyHigh grade papillary urothelial lesion (H&E). There is loss of cell adhesion, with shedding of superficial cells (A; 40x). It is a high grade lesion, with hiperchromatic nuclei that have lost polarity. (B; 10x) The epithelial layer is densely cellular and thick and the fibrovascular core shows proliferated ectatic vessels, with foci of invasion through the basement membrane (arrow)Back to article page