Fig. 2From: Current topics on prostate and bladder pathologyIntraductal carcinoma of the prostate in a prostatectomy specimen associated with invasive adenocarcinoma. a HE stain (40×) shows expanded ducts with loose and dense cribriform morphologies surrounded by small infiltrative glands of acinar adenocarcinoma. b Immunohistochemistry of a cocktail using basal cell markers (p63 and high molecular weight cytokeratin, 34BE12) and Alpha-methylacyl-CoA racemase (AMACR) (40×): intraductal carcinoma show preserved basal cell layer while luminal cells of intraductal carcinoma and invasive adenocarcinoma express AMACR. c PTEN immunohistochemistry (100×) shows loss of nuclear and cytoplasmatic express of PTEN protein in intraductal carcinoma while preserved stain is seen in adjacent stromaBack to article page