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Table 5 Comparison of pathologic features and immunohistochemistry status between the STUMP and leiomyoma groups

From: Uterine smooth muscle tumors of uncertain malignant potential: a retrospective evaluation of clinical pathology and immunohistochemistry features

Feature

Total

STUMPs

Leiomyomas

p-value

OR (95% C.I)

Tumor marker, n (%)

 Negative

43 (95.6%)

19 (90.5%)

24 (100%)

0.21*

0.16(0.01–3.51)a

 Positive

2 (4.4%)

2 (9.5%)

0 (0%)

 

Pathologic size (cm), n (%)

  < 5 (reference category)

16 (38.1%)

3 (16.7%)

13 (54.2%)

0.03†

1 (.-.)b

 5–10

16 (38.1%)

10 (55.6%)

6 (25%)

 

7.22 (1.44–36.22)b

  ≥ 10

10 (23.8%)

5 (27.8%)

5 (20.8%)

 

4.33 (0.74–25.29)b

Variants of leiomyoma, n (%)

 Conventional (reference category)

41 (91.1%)

17 (81%)

24 (100%)

0.05*

1 (.-.)a

 Epithelioid

3 (6.7%)

3 (14.3%)

0 (0%)

 

0.1 (0–2.1)a

 Myxoid

1 (2.2%)

1 (4.8%)

0 (0%)

 

0.24 (0.01–6.2)a

Mitosis (cm), n (%)

  < 5

44 (97.8%)

20 (95.2%)

24 (100%)

0.47*

0.28 (0.01–7.22)a

 5–10

1 (2.2%)

1 (4.8%)

0 (0%)

 

Necrosis, n (%)

 No (reference category)

36 (80%)

12 (57.1%)

24 (100%)

 < 0.001*

1 (.-.)a

 Hyaline

5 (11.1%)

5 (23.8%)

0 (0%)

 

0.05 (0.0–0.91)a

 Coagulation

4 (8.9%)

4 (19%)

0 (0%)

 

0.06 (0.0–1.14)a

Atypia severity, n (%)

 No (reference category)

29 (64.4%)

5 (23.8%)

24 (100%)

 < 0.001*

1 (.-.)a

 Mild to moderate

5 (11.1%)

5 (23.8%)

0 (0%)

 

0.02 (0.0–0.4)a

 Moderate to severe

9 (20%)

9 (42.9%)

0 (0%)

 

0.01 (0.0–0.22)a

 Severe

2 (4.4%)

2 (9.5%)

0 (0%)

 

0.04 (0.0–1.07)a

Atypia distribution, n (%)

 No

29 (64.4%)

5 (23.8%)

24 (100%)

 < 0.001*

1 (.-.)a

 Focal

8 (17.8%)

8 (38.1%)

0 (0%)

 

0.01 (0–0.26)a

 Diffuse

8 (17.8%)

8 (38.1%)

0 (0%)

 

0.01 (0–0.26)a

P16, n (%)

 Negative

32 (71.1%)

8 (38.1%)

24 (100%)

 < 0.001*

0.01 (0.0007–0.24)a

 Positive

13 (28.9%)

13 (61.9%)

0 (0%)

 

Bcl2, n (%)

 Negative

19 (42.2%)

5 (23.8%)

14 (58.3%)

0.03†

0.22 (0.06–0.81)b

 Positive

26 (57.8%)

16 (76.2%)

10 (41.7%)

 

P53

 Negative

45 (100%)

21 (100%)

24 (100%)

 

0.88 (0.02–46.15)a

 Positive

0 (0%)

0 (0%)

0 (0%)

 
  1. *Exact Fisher test
  2. †Chi square test
  3. acorrected OR based on Haldane’s correction, OR (95% C.I); odds ratio
  4. blogistic regression